The past, present, and future of Leishmania genomics and transcriptomics

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    Author
    Cantacessi, C; Dantas-Torres, F; Nolan, MJ; Otranto, D
    Date
    2015-03-01
    Source Title
    Trends in Parasitology
    Publisher
    ELSEVIER SCI LTD
    University of Melbourne Author/s
    Cantacessi, Cinzia
    Affiliation
    Veterinary Biosciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Cantacessi, C., Dantas-Torres, F., Nolan, M. J. & Otranto, D. (2015). The past, present, and future of Leishmania genomics and transcriptomics. TRENDS IN PARASITOLOGY, 31 (3), pp.100-108. https://doi.org/10.1016/j.pt.2014.12.012.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257218
    DOI
    10.1016/j.pt.2014.12.012
    Abstract
    It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases.

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