The past, present, and future of Leishmania genomics and transcriptomics
AuthorCantacessi, C; Dantas-Torres, F; Nolan, MJ; Otranto, D
Source TitleTrends in Parasitology
PublisherELSEVIER SCI LTD
University of Melbourne Author/sCantacessi, Cinzia
Document TypeJournal Article
CitationsCantacessi, C., Dantas-Torres, F., Nolan, M. J. & Otranto, D. (2015). The past, present, and future of Leishmania genomics and transcriptomics. TRENDS IN PARASITOLOGY, 31 (3), pp.100-108. https://doi.org/10.1016/j.pt.2014.12.012.
Access StatusOpen Access
It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases.
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