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    Suppression of inflammation by helminths: a role for the gut microbiota?

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    Author
    Giacomin, P; Croese, J; Krause, L; Loukas, A; Cantacessi, C
    Date
    2015-08-19
    Source Title
    Philosophical Transactions of the Royal Society B: Biological Sciences
    Publisher
    ROYAL SOC
    University of Melbourne Author/s
    Cantacessi, Cinzia
    Affiliation
    Veterinary Biosciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Giacomin, P., Croese, J., Krause, L., Loukas, A. & Cantacessi, C. (2015). Suppression of inflammation by helminths: a role for the gut microbiota?. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 370 (1675), https://doi.org/10.1098/rstb.2014.0296.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257278
    DOI
    10.1098/rstb.2014.0296
    Abstract
    Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host-parasite-microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation.

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