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dc.contributor.authorGiacomin, P
dc.contributor.authorCroese, J
dc.contributor.authorKrause, L
dc.contributor.authorLoukas, A
dc.contributor.authorCantacessi, C
dc.date.accessioned2020-12-21T03:36:40Z
dc.date.available2020-12-21T03:36:40Z
dc.date.issued2015-08-19
dc.identifierpii: rstb.2014.0296
dc.identifier.citationGiacomin, P., Croese, J., Krause, L., Loukas, A. & Cantacessi, C. (2015). Suppression of inflammation by helminths: a role for the gut microbiota?. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 370 (1675), https://doi.org/10.1098/rstb.2014.0296.
dc.identifier.issn0962-8436
dc.identifier.urihttp://hdl.handle.net/11343/257278
dc.description.abstractMultiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host-parasite-microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation.
dc.languageEnglish
dc.publisherROYAL SOC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSuppression of inflammation by helminths: a role for the gut microbiota?
dc.typeJournal Article
dc.identifier.doi10.1098/rstb.2014.0296
melbourne.affiliation.departmentVeterinary Biosciences
melbourne.source.titlePhilosophical Transactions of the Royal Society B: Biological Sciences
melbourne.source.volume370
melbourne.source.issue1675
dc.rights.licenseCC BY
melbourne.elementsid1254365
melbourne.contributor.authorCantacessi, Cinzia
dc.identifier.eissn1471-2970
melbourne.accessrightsOpen Access


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