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    [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

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    21
    Author
    Martin, ACBM; Fuzer, AM; Becceneri, AB; da Silva, JA; Tomasin, R; Denoyer, D; Kim, S-H; McIntyre, KA; Pearson, HB; Yeo, B; ...
    Date
    2017-09-22
    Source Title
    Oncotarget
    Publisher
    IMPACT JOURNALS LLC
    University of Melbourne Author/s
    Pouliot, Normand; Kim, Soo Hyun
    Affiliation
    Clinical Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Martin, A. C. B. M., Fuzer, A. M., Becceneri, A. B., da Silva, J. A., Tomasin, R., Denoyer, D., Kim, S. -H., McIntyre, K. A., Pearson, H. B., Yeo, B., Nagpal, A., Ling, X., Selistre-de-Araujo, H. S., Vieira, P. C., Cominetti, M. R. & Pouliot, N. (2017). [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. ONCOTARGET, 8 (42), pp.72260-72271. https://doi.org/10.18632/oncotarget.20139.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257280
    DOI
    10.18632/oncotarget.20139
    Abstract
    There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin (Zingiber officinale Roscoe) have been shown to mediate anti-tumour activity and to contribute to the anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties of ginger. Here we report on the inhibitory properties of [10]-gingerol against metastatic triple negative breast cancer (TNBC) in vitro and in vivo. We show that [10]-gingerol concentration-dependently induces apoptotic death in mouse and human TNBC cell lines in vitro. In addition, [10]-gingerol is well tolerated in vivo, induces a marked increase in caspase-3 activation and inhibits orthotopic tumour growth in a syngeneic mouse model of spontaneous breast cancer metastasis. Importantly, using both spontaneous and experimental metastasis assays, we show for the first time that [10]-gingerol significantly inhibits metastasis to multiple organs including lung, bone and brain. Remarkably, inhibition of brain metastasis was observed even when treatment was initiated after surgical removal of the primary tumour. Taken together, these results indicate that [10]-gingerol may be a safe and useful complementary therapy for the treatment of metastatic breast cancer and warrant further investigation of its efficacy, either alone or in combination with standard systemic therapies, in pre-clinical models of metastatic breast cancer and in patients.

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