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    Reporting and ideal testosterone levels in men undergoing androgen deprivation for prostate cancer-time for a rethink?

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    Author
    Cabarkapa, S; Perera, M; Sikaris, K; O'Brien, JS; Bolton, DM; Lawrentschuk, N
    Date
    2018-03-01
    Source Title
    Prostate International
    Publisher
    ELSEVIER INC
    University of Melbourne Author/s
    Lawrentschuk, Nathan; Sikaris, Kenneth; Bolton, Damien; Perera, Marlon Lakmal; CABARKAPA, SONJA
    Affiliation
    Surgery (Austin & Northern Health)
    Medical Education
    Metadata
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    Document Type
    Journal Article
    Citations
    Cabarkapa, S., Perera, M., Sikaris, K., O'Brien, J. S., Bolton, D. M. & Lawrentschuk, N. (2018). Reporting and ideal testosterone levels in men undergoing androgen deprivation for prostate cancer-time for a rethink?. PROSTATE INTERNATIONAL, 6 (1), pp.1-6. https://doi.org/10.1016/j.prnil.2017.05.003.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257302
    DOI
    10.1016/j.prnil.2017.05.003
    Abstract
    Background: This study aims to review current laboratory reporting strategies across Australia and New Zealand with a view to propose a more useful template for reporting serum testosterone in the context of prostate cancer. Materials and methods: Registered pathology laboratories in Australia and New Zealand were enrolled into the current study. An electronic or a phone survey was utilized to collect data from each participating laboratory. Obtained information included assay utilized, units reported, reference intervals, lowest reported value, and lowest detectable value. To identify recommendations for testosterone testing, a systematic search was performed across Web of Science (including MEDLINE), EMBASE, and Cochrane libraries. Results: Assessment of national pathology laboratories identified significant heterogeneity in the reporting methods. Reports typically used a "normal healthy male of 35 years of age" as a comparator but did not refer to optimal castrate levels, the lowest level that their assay was able to detect, nor did they include appended clinical guidelines relating to the prostate cancer patient cohort. Conclusions: Across Australia and New Zealand, various methods for testing and reporting serum testosterone exist, while international guidelines remain vague. The fashion in which serum testosterone levels are displayed should be re-evaluated to address the relevant clinical population and reflect an agreed-upon castrate threshold in patients undergoing androgen deprivation therapy.

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