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dc.contributor.authorCabarkapa, S
dc.contributor.authorPerera, M
dc.contributor.authorSikaris, K
dc.contributor.authorO'Brien, JS
dc.contributor.authorBolton, DM
dc.contributor.authorLawrentschuk, N
dc.date.accessioned2020-12-21T03:40:07Z
dc.date.available2020-12-21T03:40:07Z
dc.date.issued2018-03-01
dc.identifierpii: S2287-8882(17)30022-3
dc.identifier.citationCabarkapa, S., Perera, M., Sikaris, K., O'Brien, J. S., Bolton, D. M. & Lawrentschuk, N. (2018). Reporting and ideal testosterone levels in men undergoing androgen deprivation for prostate cancer-time for a rethink?. PROSTATE INTERNATIONAL, 6 (1), pp.1-6. https://doi.org/10.1016/j.prnil.2017.05.003.
dc.identifier.issn2287-8882
dc.identifier.urihttp://hdl.handle.net/11343/257302
dc.description.abstractBackground: This study aims to review current laboratory reporting strategies across Australia and New Zealand with a view to propose a more useful template for reporting serum testosterone in the context of prostate cancer. Materials and methods: Registered pathology laboratories in Australia and New Zealand were enrolled into the current study. An electronic or a phone survey was utilized to collect data from each participating laboratory. Obtained information included assay utilized, units reported, reference intervals, lowest reported value, and lowest detectable value. To identify recommendations for testosterone testing, a systematic search was performed across Web of Science (including MEDLINE), EMBASE, and Cochrane libraries. Results: Assessment of national pathology laboratories identified significant heterogeneity in the reporting methods. Reports typically used a "normal healthy male of 35 years of age" as a comparator but did not refer to optimal castrate levels, the lowest level that their assay was able to detect, nor did they include appended clinical guidelines relating to the prostate cancer patient cohort. Conclusions: Across Australia and New Zealand, various methods for testing and reporting serum testosterone exist, while international guidelines remain vague. The fashion in which serum testosterone levels are displayed should be re-evaluated to address the relevant clinical population and reflect an agreed-upon castrate threshold in patients undergoing androgen deprivation therapy.
dc.languageEnglish
dc.publisherELSEVIER INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleReporting and ideal testosterone levels in men undergoing androgen deprivation for prostate cancer-time for a rethink?
dc.typeJournal Article
dc.identifier.doi10.1016/j.prnil.2017.05.003
melbourne.affiliation.departmentSurgery (Austin & Northern Health)
melbourne.affiliation.departmentMedical Education
melbourne.affiliation.department
melbourne.source.titleProstate International
melbourne.source.volume6
melbourne.source.issue1
melbourne.source.pages1-6
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1263285
melbourne.contributor.authorLawrentschuk, Nathan
melbourne.contributor.authorSikaris, Kenneth
melbourne.contributor.authorBolton, Damien
melbourne.contributor.authorPerera, Marlon Lakmal
melbourne.contributor.authorCABARKAPA, SONJA
dc.identifier.eissn2287-903X
melbourne.accessrightsOpen Access


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