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dc.contributor.authorHaque, A
dc.contributor.authorBest, SE
dc.contributor.authorAmante, FH
dc.contributor.authorMustafah, S
dc.contributor.authorDesbarrieres, L
dc.contributor.authorde Labastida, F
dc.contributor.authorSparwasser, T
dc.contributor.authorHill, GR
dc.contributor.authorEngwerda, CR
dc.date.accessioned2020-12-21T03:41:32Z
dc.date.available2020-12-21T03:41:32Z
dc.date.issued2010-12-01
dc.identifier.citationHaque, A., Best, S. E., Amante, F. H., Mustafah, S., Desbarrieres, L., de Labastida, F., Sparwasser, T., Hill, G. R. & Engwerda, C. R. (2010). CD4(+) Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo. PLOS PATHOGENS, 6 (12), https://doi.org/10.1371/journal.ppat.1001221.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/257312
dc.description.abstractStudies in malaria patients indicate that higher frequencies of peripheral blood CD4(+) Foxp3(+) CD25(+) regulatory T (Treg) cells correlate with increased blood parasitemia. This observation implies that Treg cells impair pathogen clearance and thus may be detrimental to the host during infection. In C57BL/6 mice infected with Plasmodium berghei ANKA, depletion of Foxp3(+) cells did not improve parasite control or disease outcome. In contrast, elevating frequencies of natural Treg cells in vivo using IL-2/anti-IL-2 complexes resulted in complete protection against severe disease. This protection was entirely dependent upon Foxp3(+) cells and resulted in lower parasite biomass, impaired antigen-specific CD4(+) T and CD8(+) T cell responses that would normally promote parasite tissue sequestration in this model, and reduced recruitment of conventional T cells to the brain. Furthermore, Foxp3(+) cell-mediated protection was dependent upon CTLA-4 but not IL-10. These data show that T cell-mediated parasite tissue sequestration can be reduced by regulatory T cells in a mouse model of malaria, thereby limiting malaria-induced immune pathology.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCD4(+) Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1001221
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS Pathogens
melbourne.source.volume6
melbourne.source.issue12
dc.rights.licenseCC BY
melbourne.elementsid1266744
melbourne.contributor.authorHaque, Ashraful
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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