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    Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

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    Author
    Karlsson, SL; Thomson, N; Mutreja, A; Connor, T; Sur, D; Ali, M; Clemens, J; Dougan, G; Holmgren, J; Lebens, M
    Date
    2016-10-01
    Source Title
    PLoS Neglected Tropical Diseases
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Dougan, Gordon
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Karlsson, S. L., Thomson, N., Mutreja, A., Connor, T., Sur, D., Ali, M., Clemens, J., Dougan, G., Holmgren, J. & Lebens, M. (2016). Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. PLOS NEGLECTED TROPICAL DISEASES, 10 (10), https://doi.org/10.1371/journal.pntd.0005044.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257341
    DOI
    10.1371/journal.pntd.0005044
    Abstract
    Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mutational disruption of the methyltransferase encoded by the wbeT gene. Re-emergence of the Ogawa serotype was found to result either from expansion of an already existing Ogawa clade or reversion of the mutation in an Inaba clade. Our data suggests that such transitions are not random events but rather driven by as yet unidentified selection mechanisms based on differences in the structure of the O1 antigen or in the serotype-determining wbeT gene.

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