Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.

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Hoa, LNM; Bryant, JE; Choisy, M; Nguyet, LA; Bao, NT; Trang, NH; Chuc, NTK; Toan, TK; Saito, T; Takemae, N; ...Date
2015-10Source Title
Epidemiology and InfectionPublisher
Cambridge University Press (CUP)Affiliation
Doherty InstituteMicrobiology and Immunology
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Hoa, L. N. M., Bryant, J. E., Choisy, M., Nguyet, L. A., Bao, N. T., Trang, N. H., Chuc, N. T. K., Toan, T. K., Saito, T., Takemae, N., Horby, P., Wertheim, H. & Fox, A. (2015). Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.. Epidemiol Infect, 143 (14), pp.2959-2964. https://doi.org/10.1017/S0950268815000187.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595856Abstract
A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
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