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    Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.

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    Author
    Hoa, LNM; Bryant, JE; Choisy, M; Nguyet, LA; Bao, NT; Trang, NH; Chuc, NTK; Toan, TK; Saito, T; Takemae, N; ...
    Date
    2015-10
    Source Title
    Epidemiology and Infection
    Publisher
    Cambridge University Press (CUP)
    University of Melbourne Author/s
    Marsh, Annette; Fox (marsh), Annette
    Affiliation
    Doherty Institute
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Hoa, L. N. M., Bryant, J. E., Choisy, M., Nguyet, L. A., Bao, N. T., Trang, N. H., Chuc, N. T. K., Toan, T. K., Saito, T., Takemae, N., Horby, P., Wertheim, H. & Fox, A. (2015). Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.. Epidemiol Infect, 143 (14), pp.2959-2964. https://doi.org/10.1017/S0950268815000187.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257346
    DOI
    10.1017/S0950268815000187
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595856
    Abstract
    A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.

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