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dc.contributor.authorHoa, LNM
dc.contributor.authorBryant, JE
dc.contributor.authorChoisy, M
dc.contributor.authorNguyet, LA
dc.contributor.authorBao, NT
dc.contributor.authorTrang, NH
dc.contributor.authorChuc, NTK
dc.contributor.authorToan, TK
dc.contributor.authorSaito, T
dc.contributor.authorTakemae, N
dc.contributor.authorHorby, P
dc.contributor.authorWertheim, H
dc.contributor.authorFox, A
dc.date.accessioned2020-12-21T03:46:32Z
dc.date.available2020-12-21T03:46:32Z
dc.date.issued2015-10
dc.identifierpii: S0950268815000187
dc.identifier.citationHoa, L. N. M., Bryant, J. E., Choisy, M., Nguyet, L. A., Bao, N. T., Trang, N. H., Chuc, N. T. K., Toan, T. K., Saito, T., Takemae, N., Horby, P., Wertheim, H. & Fox, A. (2015). Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.. Epidemiol Infect, 143 (14), pp.2959-2964. https://doi.org/10.1017/S0950268815000187.
dc.identifier.issn0950-2688
dc.identifier.urihttp://hdl.handle.net/11343/257346
dc.description.abstractA reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.titlePopulation susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.
dc.typeJournal Article
dc.identifier.doi10.1017/S0950268815000187
melbourne.affiliation.departmentDoherty Institute
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleEpidemiology and Infection
melbourne.source.volume143
melbourne.source.issue14
melbourne.source.pages2959-2964
dc.rights.licenseCC BY
melbourne.elementsid1119471
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595856
melbourne.contributor.authorMarsh, Annette
melbourne.contributor.authorFox (marsh), Annette
dc.identifier.eissn1469-4409
melbourne.accessrightsOpen Access


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