dc.contributor.author | Hoa, LNM | |
dc.contributor.author | Bryant, JE | |
dc.contributor.author | Choisy, M | |
dc.contributor.author | Nguyet, LA | |
dc.contributor.author | Bao, NT | |
dc.contributor.author | Trang, NH | |
dc.contributor.author | Chuc, NTK | |
dc.contributor.author | Toan, TK | |
dc.contributor.author | Saito, T | |
dc.contributor.author | Takemae, N | |
dc.contributor.author | Horby, P | |
dc.contributor.author | Wertheim, H | |
dc.contributor.author | Fox, A | |
dc.date.accessioned | 2020-12-21T03:46:32Z | |
dc.date.available | 2020-12-21T03:46:32Z | |
dc.date.issued | 2015-10 | |
dc.identifier | pii: S0950268815000187 | |
dc.identifier.citation | Hoa, L. N. M., Bryant, J. E., Choisy, M., Nguyet, L. A., Bao, N. T., Trang, N. H., Chuc, N. T. K., Toan, T. K., Saito, T., Takemae, N., Horby, P., Wertheim, H. & Fox, A. (2015). Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.. Epidemiol Infect, 143 (14), pp.2959-2964. https://doi.org/10.1017/S0950268815000187. | |
dc.identifier.issn | 0950-2688 | |
dc.identifier.uri | http://hdl.handle.net/11343/257346 | |
dc.description.abstract | A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential. | |
dc.language | eng | |
dc.publisher | Cambridge University Press (CUP) | |
dc.title | Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012. | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1017/S0950268815000187 | |
melbourne.affiliation.department | Doherty Institute | |
melbourne.affiliation.department | Microbiology and Immunology | |
melbourne.source.title | Epidemiology and Infection | |
melbourne.source.volume | 143 | |
melbourne.source.issue | 14 | |
melbourne.source.pages | 2959-2964 | |
dc.rights.license | CC BY | |
melbourne.elementsid | 1119471 | |
melbourne.openaccess.pmc | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595856 | |
melbourne.contributor.author | Marsh, Annette | |
melbourne.contributor.author | Fox (marsh), Annette | |
dc.identifier.eissn | 1469-4409 | |
melbourne.accessrights | Open Access | |