Sugar or Fat? - Metabolic Requirements for Immunity to Viral Infections

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    Author
    Shehata, HM; Murphy, AJ; Lee, MKS; Gardiner, CM; Crowe, SM; Sanjabi, S; Finlay, DK; Palmer, CS
    Date
    2017-10-16
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Palmer, Clovis
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. & Palmer, C. S. (2017). Sugar or Fat? - Metabolic Requirements for Immunity to Viral Infections. FRONTIERS IN IMMUNOLOGY, 8 (OCT), https://doi.org/10.3389/fimmu.2017.01311.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257394
    DOI
    10.3389/fimmu.2017.01311
    Abstract
    The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.

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