Sugar or Fat? - Metabolic Requirements for Immunity to Viral Infections

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    Author
    Shehata, HM; Murphy, AJ; Lee, MKS; Gardiner, CM; Crowe, SM; Sanjabi, S; Finlay, DK; Palmer, CS
    Date
    2017-10-16
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Palmer, Clovis
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. & Palmer, C. S. (2017). Sugar or Fat? - Metabolic Requirements for Immunity to Viral Infections. FRONTIERS IN IMMUNOLOGY, 8 (OCT), https://doi.org/10.3389/fimmu.2017.01311.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257394
    DOI
    10.3389/fimmu.2017.01311
    Abstract
    The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.

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