X-ray nanoprobes and diffraction-limited storage rings: opportunities and challenges of fluorescence tomography of biological specimens
Authorde Jonge, MD; Ryan, CG; Jacobsen, CJ
Source TitleJournal of Synchrotron Radiation
PublisherINT UNION CRYSTALLOGRAPHY
University of Melbourne Author/sRyan, Christopher
AffiliationSchool of Physics
Document TypeJournal Article
Citationsde Jonge, M. D., Ryan, C. G. & Jacobsen, C. J. (2014). X-ray nanoprobes and diffraction-limited storage rings: opportunities and challenges of fluorescence tomography of biological specimens. JOURNAL OF SYNCHROTRON RADIATION, 21 (Pt 5), pp.1031-1047. https://doi.org/10.1107/S160057751401621X.
Access StatusOpen Access
X-ray nanoprobes require coherent illumination to achieve optic-limited resolution, and so will benefit directly from diffraction-limited storage rings. Here, the example of high-resolution X-ray fluorescence tomography is focused on as one of the most voracious demanders of coherent photons, since the detected signal is only a small fraction of the incident flux. Alternative schemes are considered for beam delivery, sample scanning and detectors. One must consider as well the steps before and after the X-ray experiment: sample preparation and examination conditions, and analysis complexity due to minimum dose requirements and self-absorption. By understanding the requirements and opportunities for nanoscale fluorescence tomography, one gains insight into the R&D challenges in optics and instrumentation needed to fully exploit the source advances that diffraction-limited storage rings offer.
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