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dc.contributor.authorAmissah, NA
dc.contributor.authorBuultjens, AH
dc.contributor.authorAblordey, A
dc.contributor.authorvan Dam, L
dc.contributor.authorOpoku-Ware, A
dc.contributor.authorBaines, SL
dc.contributor.authorBulach, D
dc.contributor.authorTetteh, CS
dc.contributor.authorPrah, I
dc.contributor.authorvan der Werf, TS
dc.contributor.authorFriedrich, AW
dc.contributor.authorSeemann, T
dc.contributor.authorvan Dijl, JM
dc.contributor.authorStienstra, Y
dc.contributor.authorStinear, TP
dc.contributor.authorRossen, JW
dc.date.accessioned2020-12-21T03:59:08Z
dc.date.available2020-12-21T03:59:08Z
dc.date.issued2017-10-06
dc.identifier.citationAmissah, N. A., Buultjens, A. H., Ablordey, A., van Dam, L., Opoku-Ware, A., Baines, S. L., Bulach, D., Tetteh, C. S., Prah, I., van der Werf, T. S., Friedrich, A. W., Seemann, T., van Dijl, J. M., Stienstra, Y., Stinear, T. P. & Rossen, J. W. (2017). Methicillin Resistant Staphylococcus aureus Transmission in a Ghanaian Burn Unit: The Importance of Active Surveillance in Resource-Limited Settings. FRONTIERS IN MICROBIOLOGY, 8 (OCT), https://doi.org/10.3389/fmicb.2017.01906.
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/11343/257439
dc.description.abstractObjectives:Staphylococcus aureus infections in burn patients can lead to serious complications and death. The frequency of S. aureus infection is high in low- and middle-income countries presumably due to limited resources, misuse of antibiotics and poor infection control. The objective of the present study was to apply population genomics to precisely define, for the first time, the transmission of antibiotic resistant S. aureus in a resource-limited setting in sub-Saharan Africa. Methods:Staphylococcus aureus surveillance was performed amongst burn patients and healthcare workers during a 7-months survey within the burn unit of the Korle Bu Teaching Hospital in Ghana. Results: Sixty-six S. aureus isolates (59 colonizing and 7 clinical) were obtained from 31 patients and 10 healthcare workers. Twenty-one of these isolates were ST250-IV methicillin-resistant S. aureus (MRSA). Notably, 25 (81%) of the 31 patients carried or were infected with S. aureus within 24 h of admission. Genome comparisons revealed six distinct S. aureus clones circulating in the burn unit, and demonstrated multiple transmission events between patients and healthcare workers. Further, the collected S. aureus isolates exhibited a wide range of genotypic resistances to antibiotics, including trimethoprim (21%), aminoglycosides (33%), oxacillin (33%), chloramphenicol (50%), tetracycline (59%) and fluoroquinolones (100%). Conclusion: Population genomics uncovered multiple transmission events of S. aureus, especially MRSA, within the investigated burn unit. Our findings highlight lapses in infection control and prevention, and underscore the great importance of active surveillance to protect burn victims against multi-drug resistant pathogens in resource-limited settings.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMethicillin Resistant Staphylococcus aureus Transmission in a Ghanaian Burn Unit: The Importance of Active Surveillance in Resource-Limited Settings
dc.typeJournal Article
dc.identifier.doi10.3389/fmicb.2017.01906
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleFrontiers in Microbiology
melbourne.source.volume8
melbourne.source.issueOCT
dc.rights.licenseCC BY
melbourne.elementsid1269764
melbourne.contributor.authorBaines, Sarah
melbourne.contributor.authorBuultjens, Andrew
melbourne.contributor.authorSeemann, Torsten
melbourne.contributor.authorStinear, Timothy
melbourne.contributor.authorBulach, Dieter
melbourne.contributor.authorBuultjens, Andrew
dc.identifier.eissn1664-302X
melbourne.accessrightsOpen Access


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