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dc.contributor.authorGao, J
dc.contributor.authorParsons, MW
dc.contributor.authorKawano, H
dc.contributor.authorLevi, CR
dc.contributor.authorEvans, T-J
dc.contributor.authorLin, L
dc.contributor.authorBivard, A
dc.date.accessioned2020-12-21T03:59:32Z
dc.date.available2020-12-21T03:59:32Z
dc.date.issued2017-09-01
dc.identifierpii: jos-2016-01424
dc.identifier.citationGao, J., Parsons, M. W., Kawano, H., Levi, C. R., Evans, T. -J., Lin, L. & Bivard, A. (2017). Visibility of CT Early Ischemic Change Is Significantly Associated with Time from Stroke Onset to Baseline Scan beyond the First 3 Hours of Stroke Onset. JOURNAL OF STROKE, 19 (3), pp.340-346. https://doi.org/10.5853/jos.2016.01424.
dc.identifier.issn2287-6391
dc.identifier.urihttp://hdl.handle.net/11343/257442
dc.description.abstractBACKGROUND AND PURPOSE: Non-contrast brain computed tomography (NCCT) remains the most common imaging modality employed to select patients for thrombolytic therapy in acute ischemic stroke. The current study used the Alberta Stroke Program Early CT Score (ASPECTS) to identify early ischemic changes on brain NCCT imaging with the aim to investigate whether a relationship exists between time from symptoms onset to NCCT with the presence of early ischaemic change quantified by ASPECTS. METHODS: We studied 1,329 ischemic stroke patients who had NCCT within 8 hours of stroke onset. Patients were assessed to see if they had any ASPECTS lesion and if the rate of patients with a lesion increased with time using logistic regression. RESULTS: 30% patients had an ASPECTS <10 within the first 3 hours from symptom onset. Within the first 3 hours, the odds for a CT change (ASPECTS <10) per minute of time was 1.00 with 95% confidence interval (CI) (0.99 to 1.00) (P=0.266). After 3 hours, there was a significant increase in odds of ASPECTS <10 with increasing time. The odds of being ASPECTS positive increased 1% (odds ratio=1.01) per 1 minute of time with 95% CI (1.00 to 1.01) (P=0.002). CONCLUSIONS: We have identified that prior to first 3 hours of stroke there was no effect of time on odds of CT ischemic change; after the first 3 hours of stroke the odds increased with increasing time to CT scan. The occurrence of early ischemic change may be a marker of time from stroke onset rather than severity.
dc.languageEnglish
dc.publisherKOREAN STROKE SOC
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleVisibility of CT Early Ischemic Change Is Significantly Associated with Time from Stroke Onset to Baseline Scan beyond the First 3 Hours of Stroke Onset
dc.typeJournal Article
dc.identifier.doi10.5853/jos.2016.01424
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of stroke
melbourne.source.volume19
melbourne.source.issue3
melbourne.source.pages340-346
dc.rights.licenseCC BY-NC
melbourne.elementsid1270213
melbourne.contributor.authorParsons, Mark
melbourne.contributor.authorBivard, Andrew
dc.identifier.eissn2287-6405
melbourne.accessrightsOpen Access


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