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    Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas

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    Author
    Palesi, F; De Rinaldis, A; Castellazzi, G; Calamante, F; Muhlert, N; Chard, D; Tournier, JD; Magenes, G; D'Angelo, E; Wheeler-Kingshott, CAMG
    Date
    2017-10-09
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Calamante, Fernando
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Palesi, F., De Rinaldis, A., Castellazzi, G., Calamante, F., Muhlert, N., Chard, D., Tournier, J. D., Magenes, G., D'Angelo, E. & Wheeler-Kingshott, C. A. M. G. (2017). Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-13079-8.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257444
    DOI
    10.1038/s41598-017-13079-8
    Abstract
    Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and include the cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) pathways. CTC and CPC characterization in humans in vivo is still challenging. Here advanced tractography was combined with quantitative indices to compare CPC to CTC pathways in healthy subjects. Differently to previous studies, our findings reveal that cerebellar cognitive areas are reached by the largest proportion of the reconstructed CPC, supporting the hypothesis that a CTC-CPC loop provides a substrate for cerebro-cerebellar communication during cognitive processing. Amongst the cerebral areas identified using in vivo tractography, in addition to the cerebral motor cortex, major portions of CPC streamlines leave the prefrontal and temporal cortices. These findings are useful since provide MRI-based indications of possible subtending connectivity and, if confirmed, they are going to be a milestone for instructing computational models of brain function. These results, together with further multi-modal investigations, are warranted to provide important cues on how the cerebro-cerebellar loops operate and on how pathologies involving cerebro-cerebellar connectivity are generated.

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