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dc.contributor.authorRohart, F
dc.contributor.authorGautier, B
dc.contributor.authorSingh, A
dc.contributor.authorLe Cao, K-A
dc.date.accessioned2020-12-21T04:01:00Z
dc.date.available2020-12-21T04:01:00Z
dc.date.issued2017-11-01
dc.identifierpii: PCOMPBIOL-D-17-00712
dc.identifier.citationRohart, F., Gautier, B., Singh, A. & Le Cao, K. -A. (2017). mixOmics: An R package for 'omics feature selection and multiple data integration. PLOS COMPUTATIONAL BIOLOGY, 13 (11), https://doi.org/10.1371/journal.pcbi.1005752.
dc.identifier.issn1553-734X
dc.identifier.urihttp://hdl.handle.net/11343/257448
dc.description.abstractThe advent of high throughput technologies has led to a wealth of publicly available 'omics data coming from different sources, such as transcriptomics, proteomics, metabolomics. Combining such large-scale biological data sets can lead to the discovery of important biological insights, provided that relevant information can be extracted in a holistic manner. Current statistical approaches have been focusing on identifying small subsets of molecules (a 'molecular signature') to explain or predict biological conditions, but mainly for a single type of 'omics. In addition, commonly used methods are univariate and consider each biological feature independently. We introduce mixOmics, an R package dedicated to the multivariate analysis of biological data sets with a specific focus on data exploration, dimension reduction and visualisation. By adopting a systems biology approach, the toolkit provides a wide range of methods that statistically integrate several data sets at once to probe relationships between heterogeneous 'omics data sets. Our recent methods extend Projection to Latent Structure (PLS) models for discriminant analysis, for data integration across multiple 'omics data or across independent studies, and for the identification of molecular signatures. We illustrate our latest mixOmics integrative frameworks for the multivariate analyses of 'omics data available from the package.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlemixOmics: An R package for 'omics feature selection and multiple data integration
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pcbi.1005752
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.source.titlePLoS Computational Biology
melbourne.source.volume13
melbourne.source.issue11
melbourne.identifier.nhmrc1087415
dc.rights.licenseCC BY
melbourne.elementsid1271255
melbourne.contributor.authorLe Cao, Kim-Anh
dc.identifier.eissn1553-7358
melbourne.identifier.fundernameidNHMRC, 1087415
melbourne.accessrightsOpen Access


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