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dc.contributor.authorWalkley, CR
dc.contributor.authorLi, JB
dc.date.accessioned2020-12-21T04:01:30Z
dc.date.available2020-12-21T04:01:30Z
dc.date.issued2017-10-30
dc.identifierpii: 10.1186/s13059-017-1347-3
dc.identifier.citationWalkley, C. R. & Li, J. B. (2017). Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs. GENOME BIOLOGY, 18 (1), https://doi.org/10.1186/s13059-017-1347-3.
dc.identifier.issn1474-760X
dc.identifier.urihttp://hdl.handle.net/11343/257452
dc.description.abstractOne of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
dc.typeJournal Article
dc.identifier.doi10.1186/s13059-017-1347-3
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleGenome Biology
melbourne.source.volume18
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1271360
melbourne.contributor.authorWalkley, Carl
dc.identifier.eissn1474-760X
melbourne.accessrightsOpen Access


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