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    Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.

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    Author
    Leeansyah, E; Loh, L; Nixon, DF; Sandberg, JK
    Date
    2014
    Source Title
    Nature Communications
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Loh, Liyen
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Leeansyah, E., Loh, L., Nixon, D. F. & Sandberg, J. K. (2014). Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.. Nat Commun, 5 (1), pp.3143-. https://doi.org/10.1038/ncomms4143.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257490
    DOI
    10.1038/ncomms4143
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916833
    Abstract
    Innate-like, evolutionarily conserved MR1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-cell subset in humans. Here, we investigate the development of these cells in second trimester human fetal tissues. MAIT cells are rare and immature in the fetal thymus, spleen and mesenteric lymph nodes. In contrast, mature IL-18Rα(+) CD8αα MAIT cells are enriched in the fetal small intestine, liver and lung. Independently of localization, MAIT cells express CD127 and Ki67 in vivo and readily proliferate in response to Escherichia coli in vitro. Maturation is accompanied by the gradual post-thymic acquisition of the PLZF transcription factor and the ability to produce IFNγ and IL-22 in response to bacteria in mucosa. Thus, MAIT cells acquire innate-like antimicrobial responsiveness in mucosa before exposure to environmental microbes and the commensal microflora. Establishment of this arm of immunity before birth may help protect the newborn from a range of pathogenic microbes.

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