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    Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.

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    Author
    Rafehi, H; Ververis, K; Balcerczyk, A; Ziemann, M; Ooi, J; Hu, S; Kwa, FAA; Loveridge, SJ; Georgiadis, GT; El-Osta, A; ...
    Date
    2012
    Source Title
    Pathobiology of Aging & Age-related Diseases
    Publisher
    Informa UK Limited
    University of Melbourne Author/s
    El-Osta, Assam
    Affiliation
    Clinical Pathology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Rafehi, H., Ververis, K., Balcerczyk, A., Ziemann, M., Ooi, J., Hu, S., Kwa, F. A. A., Loveridge, S. J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C. (2012). Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.. Pathobiol Aging Age Relat Dis, 2 (1), pp.11905-11905. https://doi.org/10.3402/pba.v2i0.11905.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257512
    DOI
    10.3402/pba.v2i0.11905
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697
    Abstract
    The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.

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