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dc.contributor.authorRafehi, H
dc.contributor.authorVerveris, K
dc.contributor.authorBalcerczyk, A
dc.contributor.authorZiemann, M
dc.contributor.authorOoi, J
dc.contributor.authorHu, S
dc.contributor.authorKwa, FAA
dc.contributor.authorLoveridge, SJ
dc.contributor.authorGeorgiadis, GT
dc.contributor.authorEl-Osta, A
dc.contributor.authorKaragiannis, TC
dc.date.accessioned2020-12-21T04:10:22Z
dc.date.available2020-12-21T04:10:22Z
dc.date.issued2012
dc.identifierpii: PBA-2-11905
dc.identifier.citationRafehi, H., Ververis, K., Balcerczyk, A., Ziemann, M., Ooi, J., Hu, S., Kwa, F. A. A., Loveridge, S. J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C. (2012). Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.. Pathobiol Aging Age Relat Dis, 2 (1), pp.11905-11905. https://doi.org/10.3402/pba.v2i0.11905.
dc.identifier.issn2001-0001
dc.identifier.urihttp://hdl.handle.net/11343/257512
dc.description.abstractThe accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.
dc.languageeng
dc.publisherInforma UK Limited
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleInvestigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.
dc.typeJournal Article
dc.identifier.doi10.3402/pba.v2i0.11905
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titlePathobiology of Aging & Age-related Diseases
melbourne.source.volume2
melbourne.source.issue1
melbourne.source.pages11905-11905
dc.rights.licenseCC BY-NC
melbourne.elementsid1272719
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697
melbourne.contributor.authorEl-Osta, Assam
dc.identifier.eissn2001-0001
melbourne.accessrightsOpen Access


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