Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.
AuthorTaylor, CE; Stashak, PW; Caldes, G; Prescott, B; Chused, TE; Brooks, A; Baker, PJ
Source TitleJournal of Experimental Medicine
PublisherRockefeller University Press
University of Melbourne Author/sBrooks, Andrew
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsTaylor, C. E., Stashak, P. W., Caldes, G., Prescott, B., Chused, T. E., Brooks, A. & Baker, P. J. (1983). Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.. J Exp Med, 158 (3), pp.703-717. https://doi.org/10.1084/jem.158.3.703.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187111
The transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific suppression of the antibody response of recipients immunized with SSS-III. Such suppression shares many features associated with low-dose paralysis, a phenomenon mediated by suppressor T cells; it reaches maximal levels 3 d after the transfer of viable or irradiated immune B cells and can be eliminated by the depletion of SSS-III-binding cells from spleen cell suspensions before transfer. In a two-step cell transfer experiment, purified T lymphocytes, isolated from recipients previously given immune B cells, caused suppression upon transfer to other mice immunized with SSS-III. Also, B-cell-induced suppression could be abrogated in a competitive manner by the infusion of amplifier T lymphocytes, as was previously demonstrated in the case of low-dose paralysis. These findings suggest that B cell surface components, presumably the idiotypic determinants of cell-associated antibody specific for SSS-III, are instrumental in activating suppressor T cells involved in regulating the magnitude of the antibody response to SSS-III.
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