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dc.contributor.authorTaylor, CE
dc.contributor.authorStashak, PW
dc.contributor.authorCaldes, G
dc.contributor.authorPrescott, B
dc.contributor.authorChused, TE
dc.contributor.authorBrooks, A
dc.contributor.authorBaker, PJ
dc.date.accessioned2020-12-21T04:12:22Z
dc.date.available2020-12-21T04:12:22Z
dc.date.issued1983-09-01
dc.identifier.citationTaylor, C. E., Stashak, P. W., Caldes, G., Prescott, B., Chused, T. E., Brooks, A. & Baker, P. J. (1983). Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.. J Exp Med, 158 (3), pp.703-717. https://doi.org/10.1084/jem.158.3.703.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257527
dc.description.abstractThe transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific suppression of the antibody response of recipients immunized with SSS-III. Such suppression shares many features associated with low-dose paralysis, a phenomenon mediated by suppressor T cells; it reaches maximal levels 3 d after the transfer of viable or irradiated immune B cells and can be eliminated by the depletion of SSS-III-binding cells from spleen cell suspensions before transfer. In a two-step cell transfer experiment, purified T lymphocytes, isolated from recipients previously given immune B cells, caused suppression upon transfer to other mice immunized with SSS-III. Also, B-cell-induced suppression could be abrogated in a competitive manner by the infusion of amplifier T lymphocytes, as was previously demonstrated in the case of low-dose paralysis. These findings suggest that B cell surface components, presumably the idiotypic determinants of cell-associated antibody specific for SSS-III, are instrumental in activating suppressor T cells involved in regulating the magnitude of the antibody response to SSS-III.
dc.languageeng
dc.publisherRockefeller University Press
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleActivation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.
dc.typeJournal Article
dc.identifier.doi10.1084/jem.158.3.703
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume158
melbourne.source.issue3
melbourne.source.pages703-717
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1275379
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187111
melbourne.contributor.authorBrooks, Andrew
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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