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    Identification of a Severe Acute Respiratory Syndrome Coronavirus-Like Virus in a Leaf-Nosed Bat in Nigeria

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    Author
    Quan, P-L; Firth, C; Street, C; Henriquez, JA; Petrosov, A; Tashmukhamedova, A; Hutchison, SK; Egholm, M; Osinubi, MOV; Niezgoda, M; ...
    Date
    2010-09-01
    Source Title
    mBio
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Firth, Cadhla
    Affiliation
    School of BioSciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Quan, P. -L., Firth, C., Street, C., Henriquez, J. A., Petrosov, A., Tashmukhamedova, A., Hutchison, S. K., Egholm, M., Osinubi, M. O. V., Niezgoda, M., Ogunkoya, A. B., Briese, T., Rupprecht, C. E. & Lipkin, W. I. (2010). Identification of a Severe Acute Respiratory Syndrome Coronavirus-Like Virus in a Leaf-Nosed Bat in Nigeria. MBIO, 1 (4), https://doi.org/10.1128/mBio.00208-10.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257533
    DOI
    10.1128/mBio.00208-10
    Abstract
    Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, and severe acute respiratory syndrome coronaviruses (SARS-CoVs). In the course of a project focused on pathogen discovery in contexts where human-bat contact might facilitate more efficient interspecies transmission of viruses, we surveyed gastrointestinal tissue obtained from bats collected in caves in Nigeria that are frequented by humans. Coronavirus consensus PCR and unbiased high-throughput pyrosequencing revealed the presence of coronavirus sequences related to those of SARS-CoV in a Commerson's leaf-nosed bat (Hipposideros commersoni). Additional genomic sequencing indicated that this virus, unlike subgroup 2b CoVs, which includes SARS-CoV, is unique, comprising three overlapping open reading frames between the M and N genes and two conserved stem-loop II motifs. Phylogenetic analyses in conjunction with these features suggest that this virus represents a new subgroup within group 2 CoVs.

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