Shaping Innate Lymphoid Cell Diversity
AuthorHuang, Q; Seillet, C; Belz, GT
Source TitleFrontiers in Immunology
PublisherFRONTIERS MEDIA SA
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsHuang, Q., Seillet, C. & Belz, G. T. (2017). Shaping Innate Lymphoid Cell Diversity. FRONTIERS IN IMMUNOLOGY, 8 (NOV), https://doi.org/10.3389/fimmu.2017.01569.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697340
Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces.
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