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    Shaping Innate Lymphoid Cell Diversity

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    Author
    Huang, Q; Seillet, C; Belz, GT
    Date
    2017-11-16
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Belz, Gabrielle; Seillet, Cyril; Huang, Qiutong
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Huang, Q., Seillet, C. & Belz, G. T. (2017). Shaping Innate Lymphoid Cell Diversity. FRONTIERS IN IMMUNOLOGY, 8 (NOV), https://doi.org/10.3389/fimmu.2017.01569.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257534
    DOI
    10.3389/fimmu.2017.01569
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697340
    Abstract
    Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces.

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