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dc.contributor.authorMlacki, M
dc.contributor.authorDarido, C
dc.contributor.authorJane, SM
dc.contributor.authorWilanowski, T
dc.date.accessioned2020-12-21T04:16:28Z
dc.date.available2020-12-21T04:16:28Z
dc.date.issued2014-02-20
dc.identifierpii: PONE-D-13-43974
dc.identifier.citationMlacki, M., Darido, C., Jane, S. M. & Wilanowski, T. (2014). Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin. PLOS ONE, 9 (2), https://doi.org/10.1371/journal.pone.0089247.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/257553
dc.description.abstractThe Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis. As a consequence, the epidermis of Grhl1-null mice displays fewer desmosomes that are abnormal in structure. These mice also exhibit mild chronic skin barrier defects as evidenced by altered keratinocyte terminal differentiation, increased expression of inflammatory markers and infiltration of the skin by immune cells. Exposure of Grhl1 (-/-) mice to a standard chemical skin carcinogenesis protocol results in development of fewer papillomas than in wild type control animals, but with a rate of conversion to squamous cell carcinoma (SCC) that is strikingly higher than in normal littermates. The underlying molecular mechanism differs from mice with conditional ablation of a closely related Grhl family member, Grhl3, in the skin, which develop SCC due to the loss of expression of phosphatase and tensin homolog (PTEN) and activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) signaling pathway.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLoss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0089247
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titlePLoS One
melbourne.source.volume9
melbourne.source.issue2
melbourne.identifier.nhmrc628365
dc.rights.licenseCC BY
melbourne.elementsid1180355
melbourne.contributor.authorDarido, Charbel
dc.identifier.eissn1932-6203
melbourne.identifier.fundernameidNHMRC, 628365
melbourne.accessrightsOpen Access


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