University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Engineering and Information Technology
  • Biomedical Engineering
  • Biomedical Engineering - Research Publications
  • View Item
  • Minerva Access
  • Engineering and Information Technology
  • Biomedical Engineering
  • Biomedical Engineering - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation

    Thumbnail
    Download
    published version (1.195Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    14
    13
    Author
    Niclis, JC; Turner, C; Durnall, J; McDougal, S; Kauhausen, JA; Leaw, B; Dottori, M; Parish, CL; Thompson, LH
    Date
    2017-06-01
    Source Title
    Stem Cells Translational Medicine
    Publisher
    WILEY
    University of Melbourne Author/s
    Thompson, Lachlan; Dottori, Mirella; Parish, Clare; McDougall, Stuart; Kauhausen, Jessica
    Affiliation
    Biomedical Engineering
    Florey Department of Neuroscience and Mental Health
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Niclis, J. C., Turner, C., Durnall, J., McDougal, S., Kauhausen, J. A., Leaw, B., Dottori, M., Parish, C. L. & Thompson, L. H. (2017). Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation. STEM CELLS TRANSLATIONAL MEDICINE, 6 (6), pp.1547-1556. https://doi.org/10.1002/sctm.16-0198.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257579
    DOI
    10.1002/sctm.16-0198
    Abstract
    The capacity for induced pluripotent stem (iPS) cells to be differentiated into a wide range of neural cell types makes them an attractive donor source for autologous neural transplantation therapies aimed at brain repair. Translation to the in vivo setting has been difficult, however, with mixed results in a wide variety of preclinical models of brain injury and limited information on the basic in vivo properties of neural grafts generated from human iPS cells. Here we have generated a human iPS cell line constitutively expressing green fluorescent protein as a basis to identify and characterize grafts resulting from transplantation of neural progenitors into the adult rat brain. The results show that the grafts contain a mix of neural cell types, at various stages of differentiation, including neurons that establish extensive patterns of axonal growth and progressively develop functional properties over the course of 1 year after implantation. These findings form an important basis for the design and interpretation of preclinical studies using human stem cells for functional circuit re-construction in animal models of brain injury. Stem Cells Translational Medicine 2017;6:1547-1556.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53039]
    • Anatomy and Neuroscience - Research Publications [805]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1300]
    • Biomedical Engineering - Research Publications [183]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors