Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
AuthorBernatsky, S; Garcia, HAV; Spinelli, JJ; Gaffney, P; Smedby, KE; Ramsey-Goldman, R; Wang, SS; Adami, H-O; Albanes, D; Angelucci, E; ...
Source TitleLupus Science & Medicine
PublisherBMJ PUBLISHING GROUP
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsBernatsky, S., Garcia, H. A. V., Spinelli, J. J., Gaffney, P., Smedby, K. E., Ramsey-Goldman, R., Wang, S. S., Adami, H. -O., Albanes, D., Angelucci, E., Ansell, S. M., Asmann, Y. W., Becker, N., Benavente, Y., Berndt, S. I., Bertrand, K. A., Birmann, B. M., Boeing, H., Boffetta, P. ,... Clarke, A. E. (2017). Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. LUPUS SCIENCE & MEDICINE, 4 (1), https://doi.org/10.1136/lupus-2016-000187.
Access StatusOpen Access
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
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