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dc.contributor.authorBernatsky, S
dc.contributor.authorGarcia, HAV
dc.contributor.authorSpinelli, JJ
dc.contributor.authorGaffney, P
dc.contributor.authorSmedby, KE
dc.contributor.authorRamsey-Goldman, R
dc.contributor.authorWang, SS
dc.contributor.authorAdami, H-O
dc.contributor.authorAlbanes, D
dc.contributor.authorAngelucci, E
dc.contributor.authorAnsell, SM
dc.contributor.authorAsmann, YW
dc.contributor.authorBecker, N
dc.contributor.authorBenavente, Y
dc.contributor.authorBerndt, SI
dc.contributor.authorBertrand, KA
dc.contributor.authorBirmann, BM
dc.contributor.authorBoeing, H
dc.contributor.authorBoffetta, P
dc.contributor.authorBracci, PM
dc.contributor.authorBrennan, P
dc.contributor.authorBrooks-Wilson, AR
dc.contributor.authorCerhan, JR
dc.contributor.authorChanock, SJ
dc.contributor.authorClavel, J
dc.contributor.authorConde, L
dc.contributor.authorCotenbader, KH
dc.contributor.authorCox, DG
dc.contributor.authorCozen, W
dc.contributor.authorCrouch, S
dc.contributor.authorDe Roos, AJ
dc.contributor.authorde Sanjose, S
dc.contributor.authorDi Lollo, S
dc.contributor.authorDiver, WR
dc.contributor.authorDogan, A
dc.contributor.authorForetova, L
dc.contributor.authorGhesquieres, H
dc.contributor.authorGiles, GG
dc.contributor.authorGlimelius, B
dc.contributor.authorHabermann, TM
dc.contributor.authorHaioun, C
dc.contributor.authorHartge, P
dc.contributor.authorHjalgrim, H
dc.contributor.authorHolford, TR
dc.contributor.authorHolly, EA
dc.contributor.authorJackson, RD
dc.contributor.authorKaaks, R
dc.contributor.authorKane, E
dc.contributor.authorKelly, RS
dc.contributor.authorKlein, RJ
dc.contributor.authorKraft, P
dc.contributor.authorKricker, A
dc.contributor.authorLan, Q
dc.contributor.authorLawrence, C
dc.contributor.authorLiebow, M
dc.contributor.authorLightfoot, T
dc.contributor.authorLink, BK
dc.contributor.authorMaynadie, M
dc.contributor.authorMckay, J
dc.contributor.authorMelbye, M
dc.contributor.authorMolina, TJ
dc.contributor.authorMonnereau, A
dc.contributor.authorMorton, LM
dc.contributor.authorNieters, A
dc.contributor.authorNorth, KE
dc.contributor.authorNovak, AJ
dc.contributor.authorOffit, K
dc.contributor.authorPurdue, MP
dc.contributor.authorRais, M
dc.contributor.authorRiby, J
dc.contributor.authorRoman, E
dc.contributor.authorRothman, N
dc.contributor.authorSalles, G
dc.contributor.authorSeveri, G
dc.contributor.authorSeverson, RK
dc.contributor.authorSkibola, CF
dc.contributor.authorSlager, SL
dc.contributor.authorSmith, A
dc.contributor.authorSmith, MT
dc.contributor.authorSouthey, MC
dc.contributor.authorStaines, A
dc.contributor.authorTeras, LR
dc.contributor.authorThompson, CA
dc.contributor.authorTilly, H
dc.contributor.authorTinker, LF
dc.contributor.authorTjonneland, A
dc.contributor.authorTurner, J
dc.contributor.authorVajdic, CM
dc.contributor.authorVermeulen, RCH
dc.contributor.authorVijai, J
dc.contributor.authorVineis, P
dc.contributor.authorVirtamo, J
dc.contributor.authorWang, Z
dc.contributor.authorWeinstein, S
dc.contributor.authorWitzig, TE
dc.contributor.authorZelenetz, A
dc.contributor.authorZeleniuch-Jacquotte, A
dc.contributor.authorZhang, Y
dc.contributor.authorZheng, T
dc.contributor.authorZucca, M
dc.contributor.authorClarke, AE
dc.date.accessioned2020-12-21T04:24:45Z
dc.date.available2020-12-21T04:24:45Z
dc.date.issued2017-01-01
dc.identifierpii: lupus-2016-000187
dc.identifier.citationBernatsky, S., Garcia, H. A. V., Spinelli, J. J., Gaffney, P., Smedby, K. E., Ramsey-Goldman, R., Wang, S. S., Adami, H. -O., Albanes, D., Angelucci, E., Ansell, S. M., Asmann, Y. W., Becker, N., Benavente, Y., Berndt, S. I., Bertrand, K. A., Birmann, B. M., Boeing, H., Boffetta, P. ,... Clarke, A. E. (2017). Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. LUPUS SCIENCE & MEDICINE, 4 (1), https://doi.org/10.1136/lupus-2016-000187.
dc.identifier.issn2053-8790
dc.identifier.urihttp://hdl.handle.net/11343/257613
dc.description.abstractObjective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.titleLupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
dc.typeJournal Article
dc.identifier.doi10.1136/lupus-2016-000187
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleLupus Science & Medicine
melbourne.source.volume4
melbourne.source.issue1
dc.rights.licenseCC BY-NC
melbourne.elementsid1282305
melbourne.contributor.authorSeveri, Gianluca
melbourne.contributor.authorSouthey, Melissa
melbourne.contributor.authorGiles, Graham
dc.identifier.eissn2053-8790
melbourne.accessrightsOpen Access


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