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dc.contributor.authorHayward, KS
dc.contributor.authorNeva, JL
dc.contributor.authorMang, CS
dc.contributor.authorPeters, S
dc.contributor.authorWadden, KP
dc.contributor.authorFerris, JK
dc.contributor.authorBoyd, LA
dc.date.accessioned2020-12-21T04:26:10Z
dc.date.available2020-12-21T04:26:10Z
dc.date.issued2017-01-01
dc.identifier.citationHayward, K. S., Neva, J. L., Mang, C. S., Peters, S., Wadden, K. P., Ferris, J. K. & Boyd, L. A. (2017). Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke. NEURAL PLASTICITY, 2017, https://doi.org/10.1155/2017/4281532.
dc.identifier.issn2090-5904
dc.identifier.urihttp://hdl.handle.net/11343/257623
dc.description.abstractBackground: Severity of arm impairment alone does not explain motor outcomes in people with severe impairment post stroke. Objective: Define the contribution of brain biomarkers to upper limb motor outcomes in people with severe arm impairment post stroke. Methods: Paretic arm impairment (Fugl-Meyer upper limb, FM-UL) and function (Wolf Motor Function Test rate, WMFT-rate) were measured in 15 individuals with severe (FM-UL ≤ 30/66) and 14 with mild-moderate (FM-UL > 40/66) impairment. Transcranial magnetic stimulation and diffusion weight imaging indexed structure and function of the corticospinal tract and corpus callosum. Separate models of the relationship between possible biomarkers and motor outcomes at a single chronic (≥6 months) time point post stroke were performed. Results: Age (ΔR20.365, p = 0.017) and ipsilesional-transcallosal inhibition (ΔR20.182, p = 0.048) explained a 54.7% (p = 0.009) variance in paretic WMFT-rate. Prefrontal corpus callous fractional anisotropy (PF-CC FA) alone explained 49.3% (p = 0.007) variance in FM-UL outcome. The same models did not explain significant variance in mild-moderate stroke. In the severe group, k-means cluster analysis of PF-CC FA distinguished two subgroups, separated by a clinically meaningful and significant difference in motor impairment (p = 0.049) and function (p = 0.006) outcomes. Conclusion: Corpus callosum function and structure were identified as possible biomarkers of motor outcome in people with chronic and severe arm impairment.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInterhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke
dc.typeJournal Article
dc.identifier.doi10.1155/2017/4281532
melbourne.affiliation.departmentPhysiotherapy
melbourne.source.titleNeural Plasticity
melbourne.source.volume2017
melbourne.identifier.nhmrc1088449
dc.rights.licenseCC BY
melbourne.elementsid1283803
melbourne.contributor.authorHayward, Kathryn
dc.identifier.eissn1687-5443
melbourne.identifier.fundernameidNHMRC, 1088449
melbourne.accessrightsOpen Access


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