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dc.contributor.authorKoo, MM
dc.contributor.authorHamilton, W
dc.contributor.authorWalter, FM
dc.contributor.authorRubin, GP
dc.contributor.authorLyratzopoulos, G
dc.date.accessioned2020-12-21T04:26:34Z
dc.date.available2020-12-21T04:26:34Z
dc.date.issued2018-02-01
dc.identifierpii: S1476-5586(17)30426-8
dc.identifier.citationKoo, M. M., Hamilton, W., Walter, F. M., Rubin, G. P. & Lyratzopoulos, G. (2018). Symptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence. NEOPLASIA, 20 (2), pp.165-174. https://doi.org/10.1016/j.neo.2017.11.005.
dc.identifier.issn1476-5586
dc.identifier.urihttp://hdl.handle.net/11343/257626
dc.description.abstractEarly diagnosis is an important aspect of contemporary cancer prevention and control strategies, as the majority of patients are diagnosed following symptomatic presentation. The nature of presenting symptoms can critically influence the length of the diagnostic intervals from symptom onset to presentation (the patient interval), and from first presentation to specialist referral (the primary care interval). Understanding which symptoms are associated with longer diagnostic intervals to help the targeting of early diagnosis initiatives is an area of emerging research. In this Review, we consider the methodological challenges in studying the presenting symptoms and intervals to diagnosis of cancer patients, and summarize current evidence on presenting symptoms associated with a range of common and rarer cancer sites. We propose a taxonomy of cancer sites considering their symptom signature and the predictive value of common presenting symptoms. Finally, we consider evidence on associations between symptomatic presentations and intervals to diagnosis before discussing implications for the design, implementation, and evaluation of public health or health system interventions to achieve the earlier detection of cancer.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSymptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence
dc.typeJournal Article
dc.identifier.doi10.1016/j.neo.2017.11.005
melbourne.affiliation.departmentGeneral Practice
melbourne.source.titleNeoplasia
melbourne.source.volume20
melbourne.source.issue2
melbourne.source.pages165-174
dc.rights.licenseCC BY
melbourne.elementsid1284345
melbourne.contributor.authorWalter, Fiona
dc.identifier.eissn1476-5586
melbourne.accessrightsOpen Access


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