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dc.contributor.authorLi, L-J
dc.contributor.authorKramer, M
dc.contributor.authorTapp, RJ
dc.contributor.authorMan, REK
dc.contributor.authorLek, N
dc.contributor.authorCai, S
dc.contributor.authorYap, F
dc.contributor.authorGluckman, P
dc.contributor.authorTan, KH
dc.contributor.authorChong, YS
dc.contributor.authorKoh, JY
dc.contributor.authorSaw, SM
dc.contributor.authorCheung, YB
dc.contributor.authorWong, TY
dc.date.accessioned2020-12-21T04:26:50Z
dc.date.available2020-12-21T04:26:50Z
dc.date.issued2017-01-18
dc.identifierpii: 10.1186/s12886-016-0398-7
dc.identifier.citationLi, L. -J., Kramer, M., Tapp, R. J., Man, R. E. K., Lek, N., Cai, S., Yap, F., Gluckman, P., Tan, K. H., Chong, Y. S., Koh, J. Y., Saw, S. M., Cheung, Y. B. & Wong, T. Y. (2017). Gestational diabetes mellitus and retinal microvasculature. BMC OPHTHALMOLOGY, 17 (1), https://doi.org/10.1186/s12886-016-0398-7.
dc.identifier.issn1471-2415
dc.identifier.urihttp://hdl.handle.net/11343/257627
dc.description.abstractBACKGROUND: Small-vessel dysfunction may be an important consequence of chronic hyperglycemia. We examined the association between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnancy, and retinal microvascular changes in pregnant women at 26-28 weeks of pregnancy. METHODS: A total of 1136 pregnant women with singleton pregnancies were recruited during their first trimester at two major Singapore maternity hospitals in an on-going birth cohort study. Participants underwent an oral glucose tolerance test and retinal imaging at 26-28 weeks gestation (n = 542). We used the 1999 World Health Organization (WHO) criteria to define GDM: ≥7.0 mmol/L for fasting glucose and/or ≥7.8 mmol/L for 2-h post-glucose. Retinal microvasculature was measured using computer software (Singapore I Vessel Analyzer, SIVA version 3.0, Singapore Eye Research Institute, Singapore) from the retinal photographs. RESULTS: In a multiple linear regression model adjusting for age, ethnicity and maternal education, mothers with GDM had narrower arteriolar caliber (-1.6 μm; 95% Confidence Interval [CI]: -3.1 μm, -0.2 μm), reduced arteriolar fractal dimension (-0.01 Df; 95% CI: -0.02 Df, -0.001 Df;), and larger arteriolar branching angle (1.8°; 95% CI: 0.3°, 3.3°) than mothers without GDM. After further adjusting for traditional risks of GDM, arteriolar branching angle remained significantly larger in mothers with GDM than those without GDM (2.0°; 95% CI: 0.5°, 3.6°). CONCLUSIONS: GDM was associated with a series of retinal arteriolar abnormalities, including narrower caliber, reduced fractal dimension and larger branching angle, suggesting that transient hyperglycemia during pregnancy may cause small-vessel dysfunction.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGestational diabetes mellitus and retinal microvasculature
dc.typeJournal Article
dc.identifier.doi10.1186/s12886-016-0398-7
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.department
melbourne.source.titleBMC Ophthalmology
melbourne.source.volume17
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1184136
melbourne.contributor.authorWong, Tien
melbourne.contributor.authorTapp, Robyn
melbourne.contributor.authorMAN, EYN
dc.identifier.eissn1471-2415
melbourne.accessrightsOpen Access


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