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dc.contributor.authorVillalon-Letelier, F
dc.contributor.authorBrooks, AG
dc.contributor.authorSaunders, PM
dc.contributor.authorLondrigan, SL
dc.contributor.authorReading, PC
dc.date.accessioned2020-12-21T04:29:43Z
dc.date.available2020-12-21T04:29:43Z
dc.date.issued2017-12-01
dc.identifierpii: v9120376
dc.identifier.citationVillalon-Letelier, F., Brooks, A. G., Saunders, P. M., Londrigan, S. L. & Reading, P. C. (2017). Host Cell Restriction Factors that Limit Influenza A Infection. VIRUSES-BASEL, 9 (12), https://doi.org/10.3390/v9120376.
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11343/257647
dc.description.abstractViral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast majority have not been functionally characterised. Cellular proteins with putative antiviral activity (hereafter referred to as "restriction factors") can target various steps in the virus life-cycle. In the context of influenza virus infection, restriction factors have been described that target virus entry, genomic replication, translation and virus release. Genome wide analyses, in combination with ectopic overexpression and/or gene silencing studies, have accelerated the identification of restriction factors that are active against influenza and other viruses, as well as providing important insights regarding mechanisms of antiviral activity. Herein, we review current knowledge regarding restriction factors that mediate anti-influenza virus activity and consider the viral countermeasures that are known to limit their impact. Moreover, we consider the strengths and limitations of experimental approaches to study restriction factors, discrepancies between in vitro and in vivo studies, and the potential to exploit restriction factors to limit disease caused by influenza and other respiratory viruses.
dc.languageEnglish
dc.publisherMDPI
dc.titleHost Cell Restriction Factors that Limit Influenza A Infection
dc.typeJournal Article
dc.identifier.doi10.3390/v9120376
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.department
melbourne.source.titleViruses
melbourne.source.volume9
melbourne.source.issue12
dc.rights.licenseCC BY
melbourne.elementsid1285294
melbourne.contributor.authorSaunders, Philippa
melbourne.contributor.authorVillalon Letelier, Fernando Javier
melbourne.contributor.authorBrooks, Andrew
melbourne.contributor.authorLondrigan, Sarah
melbourne.contributor.authorReading, Patrick
dc.identifier.eissn1999-4915
melbourne.accessrightsOpen Access


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