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    Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles.

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    Author
    Lin, G; Cortez-Jugo, C; Ju, Y; Besford, QA; Ryan, TM; Pan, S; Richardson, JJ; Caruso, F
    Date
    2020-12-18
    Source Title
    Biomacromolecules
    Publisher
    American Chemical Society (ACS)
    University of Melbourne Author/s
    Ju, Yi; Caruso, Francesco; Besford, Quinn; Richardson, Joseph
    Affiliation
    Chemical and Biomolecular Engineering
    Metadata
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    Document Type
    Journal Article
    Citations
    Lin, G., Cortez-Jugo, C., Ju, Y., Besford, Q. A., Ryan, T. M., Pan, S., Richardson, J. J. & Caruso, F. (2020). Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles.. Biomacromolecules, https://doi.org/10.1021/acs.biomac.0c01463.
    Access Status
    This item is embargoed and will be available on 2021-12-18
    URI
    http://hdl.handle.net/11343/257662
    DOI
    10.1021/acs.biomac.0c01463
    NHMRC Grant code
    NHMRC/1135806
    Abstract
    Poly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduce immune system clearance in vivo, making PEG-based NPs (particularly sub-100 nm) of interest for diverse biomedical applications. However, the preparation of sub-100 nm PEG NPs with controllable size and morphology is challenging. Herein, we report a strategy based on the noncovalent coordination between PEG-polyphenolic ligands (PEG-gallol) and transition metal ions using a water-in-oil microemulsion phase to synthesize sub-100 nm PEG NPs with tunable size and morphology. The metal-phenolic coordination drives the self-assembly of the PEG-gallol/metal NPs: complexation between MnII and PEG-gallol within the microemulsions yields a series of metal-stabilized PEG NPs, including 30-50 nm solid and hollow NPs, depending on the MnII/gallol feed ratio. Variations in size and morphology are attributed to the changes in hydrophobicity of the PEG-gallol/MnII complexes at varying MnII/gallol ratios based on contact angle measurements. Small-angle X-ray scattering analysis, which is used to monitor the particle size and intermolecular interactions during NP evolution, reveals that ionic interactions are the dominant driving force in the formation of the PEG-gallol/MnII NPs. pH and cytotoxicity studies, and the low-fouling properties of the PEG-gallol/MnII NPs confirm their high biocompatibility and functionality, suggesting that PEG polyphenol-metal NPs are promising systems for biomedical applications.

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