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dc.contributor.authorLin, G
dc.contributor.authorCortez-Jugo, C
dc.contributor.authorJu, Y
dc.contributor.authorBesford, QA
dc.contributor.authorRyan, TM
dc.contributor.authorPan, S
dc.contributor.authorRichardson, JJ
dc.contributor.authorCaruso, F
dc.identifier.citationLin, G., Cortez-Jugo, C., Ju, Y., Besford, Q. A., Ryan, T. M., Pan, S., Richardson, J. J. & Caruso, F. (2021). Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles. BIOMACROMOLECULES, 22 (2), pp.612-619.
dc.description.abstractPoly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduce immune system clearance in vivo, making PEG-based NPs (particularly sub-100 nm) of interest for diverse biomedical applications. However, the preparation of sub-100 nm PEG NPs with controllable size and morphology is challenging. Herein, we report a strategy based on the noncovalent coordination between PEG-polyphenolic ligands (PEG-gallol) and transition metal ions using a water-in-oil microemulsion phase to synthesize sub-100 nm PEG NPs with tunable size and morphology. The metal-phenolic coordination drives the self-assembly of the PEG-gallol/metal NPs: complexation between MnII and PEG-gallol within the microemulsions yields a series of metal-stabilized PEG NPs, including 30-50 nm solid and hollow NPs, depending on the MnII/gallol feed ratio. Variations in size and morphology are attributed to the changes in hydrophobicity of the PEG-gallol/MnII complexes at varying MnII/gallol ratios based on contact angle measurements. Small-angle X-ray scattering analysis, which is used to monitor the particle size and intermolecular interactions during NP evolution, reveals that ionic interactions are the dominant driving force in the formation of the PEG-gallol/MnII NPs. pH and cytotoxicity studies, and the low-fouling properties of the PEG-gallol/MnII NPs confirm their high biocompatibility and functionality, suggesting that PEG polyphenol-metal NPs are promising systems for biomedical applications.
dc.titleMicroemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles
dc.typeJournal Article
melbourne.affiliation.departmentChemical and Biomolecular Engineering
melbourne.contributor.authorJu, Yi
melbourne.contributor.authorCaruso, Francesco
melbourne.contributor.authorBesford, Quinn
melbourne.contributor.authorRichardson, Joseph
melbourne.contributor.authorCortez-Jugo, Christina
melbourne.contributor.authorPan, Shuaijun
melbourne.identifier.fundernameidUNIVERSITY OF MELBOURNE, CE140100036
melbourne.identifier.fundernameidNHMRC, 1135806
melbourne.accessrightsThis item is embargoed and will be available on 2021-12-18

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