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dc.contributor.authorTraylor, M
dc.contributor.authorMalik, R
dc.contributor.authorNalls, MA
dc.contributor.authorCotlarciuc, I
dc.contributor.authorRadmanesh, F
dc.contributor.authorThorleifsson, G
dc.contributor.authorHanscombe, KB
dc.contributor.authorLangefeld, C
dc.contributor.authorSaleheen, D
dc.contributor.authorRost, NS
dc.contributor.authorYet, I
dc.contributor.authorSpector, TD
dc.contributor.authorBell, JT
dc.contributor.authorHannon, E
dc.contributor.authorMill, J
dc.contributor.authorChauhan, G
dc.contributor.authorDebette, S
dc.contributor.authorBis, JC
dc.contributor.authorLongstreth, WT
dc.contributor.authorIkram, MA
dc.contributor.authorLauner, LJ
dc.contributor.authorSeshadri, S
dc.contributor.authorHamilton-Bruce, MA
dc.contributor.authorJimenez-Conde, J
dc.contributor.authorCole, JW
dc.contributor.authorSchmidt, R
dc.contributor.authorSlowik, A
dc.contributor.authorLemmens, R
dc.contributor.authorLindgren, A
dc.contributor.authorMelander, O
dc.contributor.authorGrewal, RP
dc.contributor.authorSacco, RL
dc.contributor.authorRundek, T
dc.contributor.authorRexrode, K
dc.contributor.authorArnett, DK
dc.contributor.authorJohnson, JA
dc.contributor.authorBenavente, OR
dc.contributor.authorWasssertheil-Smoller, S
dc.contributor.authorLee, J-M
dc.contributor.authorPulit, SL
dc.contributor.authorWong, Q
dc.contributor.authorRich, SS
dc.contributor.authorde Bakker, PIW
dc.contributor.authorMcArdle, PF
dc.contributor.authorWoo, D
dc.contributor.authorAnderson, CD
dc.contributor.authorXu, H
dc.contributor.authorHeitsch, L
dc.contributor.authorFornage, M
dc.contributor.authorJern, C
dc.contributor.authorStefansson, K
dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorGretarsdottir, S
dc.contributor.authorLewis, CM
dc.contributor.authorSharma, P
dc.contributor.authorSudlow, CLM
dc.contributor.authorRothwell, PM
dc.contributor.authorBoncoraglio, GB
dc.contributor.authorThijs, V
dc.contributor.authorLevi, C
dc.contributor.authorMeschia, JF
dc.contributor.authorRosand, J
dc.contributor.authorKittner, SJ
dc.contributor.authorMitchell, BD
dc.contributor.authorDichgans, M
dc.contributor.authorWorrall, BB
dc.contributor.authorMarkus, HS
dc.date.accessioned2020-12-22T02:38:02Z
dc.date.available2020-12-22T02:38:02Z
dc.date.issued2017-03-01
dc.identifier.citationTraylor, M., Malik, R., Nalls, M. A., Cotlarciuc, I., Radmanesh, F., Thorleifsson, G., Hanscombe, K. B., Langefeld, C., Saleheen, D., Rost, N. S., Yet, I., Spector, T. D., Bell, J. T., Hannon, E., Mill, J., Chauhan, G., Debette, S., Bis, J. C., Longstreth, W. T. ,... Markus, H. S. (2017). Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke. ANNALS OF NEUROLOGY, 81 (3), pp.383-394. https://doi.org/10.1002/ana.24840.
dc.identifier.issn0364-5134
dc.identifier.urihttp://hdl.handle.net/11343/257677
dc.description.abstractOBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger-onset SVS population, to identify novel associations with stroke. METHODS: We used a three-stage age-at-onset informed GWAS to identify novel genetic variants associated with stroke. On identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger RNA (mRNA) expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain. RESULTS: We identified an association with SVS in 4,203 cases and 50,728 controls on chromosome 16q24.2 (odds ratio [OR; 95% confidence interval {CI}] = 1.16 [1.10-1.22]; p = 3.2 × 10-9 ). The lead single-nucleotide polymorphism (rs12445022) was also associated with cerebral white matter hyperintensities (OR [95% CI] = 1.10 [1.05-1.16]; p = 5.3 × 10-5 ; N = 3,670), but not intracerebral hemorrhage (OR [95% CI] = 0.97 [0.84-1.12]; p = 0.71; 1,545 cases, 1,481 controls). rs12445022 is associated with mRNA expression of ZCCHC14 in arterial tissues (p = 9.4 × 10-7 ) and DNA methylation at probe cg16596957 in whole blood (p = 5.3 × 10-6 ). INTERPRETATION: 16q24.2 is associated with SVS. Associations of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements. Ann Neurol 2017;81:383-394.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenetic Variation at 16q24.2 Is Associated With Small Vessel Stroke
dc.typeJournal Article
dc.identifier.doi10.1002/ana.24840
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleAnnals of Neurology
melbourne.source.volume81
melbourne.source.issue3
melbourne.source.pages383-394
dc.rights.licenseCC BY
melbourne.elementsid1123089
melbourne.contributor.authorThijs, Vincent
dc.identifier.eissn1531-8249
melbourne.accessrightsOpen Access


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