MACROPHAGE PLASMINOGEN ACTIVATOR - INDUCTION BY ASBESTOS IS BLOCKED BY ANTI-INFLAMMATORY STEROIDS

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    Author
    HAMILTON, J; VASSALLI, JD; REICH, E
    Date
    1976-01-01
    Source Title
    Journal of Experimental Medicine
    Publisher
    ROCKEFELLER UNIV PRESS
    University of Melbourne Author/s
    Hamilton, John
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    HAMILTON, J., VASSALLI, J. D. & REICH, E. (1976). MACROPHAGE PLASMINOGEN ACTIVATOR - INDUCTION BY ASBESTOS IS BLOCKED BY ANTI-INFLAMMATORY STEROIDS. JOURNAL OF EXPERIMENTAL MEDICINE, 144 (6), pp.1689-1694. https://doi.org/10.1084/jem.144.6.1689.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257691
    DOI
    10.1084/jem.144.6.1689
    Abstract
    Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.

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