MACROPHAGE PLASMINOGEN ACTIVATOR - INDUCTION BY ASBESTOS IS BLOCKED BY ANTI-INFLAMMATORY STEROIDS

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Author
HAMILTON, J; VASSALLI, JD; REICH, EDate
1976-01-01Source Title
Journal of Experimental MedicinePublisher
ROCKEFELLER UNIV PRESSUniversity of Melbourne Author/s
Hamilton, JohnAffiliation
Medicine and RadiologyMetadata
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Journal ArticleCitations
HAMILTON, J., VASSALLI, J. D. & REICH, E. (1976). MACROPHAGE PLASMINOGEN ACTIVATOR - INDUCTION BY ASBESTOS IS BLOCKED BY ANTI-INFLAMMATORY STEROIDS. JOURNAL OF EXPERIMENTAL MEDICINE, 144 (6), pp.1689-1694. https://doi.org/10.1084/jem.144.6.1689.Access Status
Open AccessAbstract
Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
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