MACROPHAGE TUMOR-CELL LINE AND PLASMINOGEN ACTIVATOR - POTENTIAL MODEL SYSTEM FOR MACROPHAGE REGULATION OF ENZYME-PRODUCTION
AuthorHAMILTON, JA; RALPH, P; MOORE, MAS
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sHamilton, John
AffiliationMedicine and Radiology
Document TypeJournal Article
CitationsHAMILTON, J. A., RALPH, P. & MOORE, M. A. S. (1978). MACROPHAGE TUMOR-CELL LINE AND PLASMINOGEN ACTIVATOR - POTENTIAL MODEL SYSTEM FOR MACROPHAGE REGULATION OF ENZYME-PRODUCTION. JOURNAL OF EXPERIMENTAL MEDICINE, 148 (3), pp.811-816. https://doi.org/10.1084/jem.148.3.811.
Access StatusOpen Access
The macrophage cell line, RAW264.10, synthesizes and secretes plasminogen activator. Production of this enzyme is inhibited by low concentrations of glucocorticoids and increased by phorbol myristate acetate. It is proposed that this line could be a suitable model for the regulation of enzyme synthesis by mouse peritoneal macrophages.
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