dc.contributor.author | Jorissen, RN | |
dc.contributor.author | Christie, M | |
dc.contributor.author | Mouradov, D | |
dc.contributor.author | Sakthianandeswaren, A | |
dc.contributor.author | Li, S | |
dc.contributor.author | Love, C | |
dc.contributor.author | Xu, Z-Z | |
dc.contributor.author | Molloy, PL | |
dc.contributor.author | Jones, IT | |
dc.contributor.author | McLaughlin, S | |
dc.contributor.author | Ward, RL | |
dc.contributor.author | Hawkins, NJ | |
dc.contributor.author | Ruszkiewicz, AR | |
dc.contributor.author | Moore, J | |
dc.contributor.author | Burgess, AW | |
dc.contributor.author | Busam, D | |
dc.contributor.author | Zhao, Q | |
dc.contributor.author | Strausberg, RL | |
dc.contributor.author | Lipton, L | |
dc.contributor.author | Desai, J | |
dc.contributor.author | Gibbs, P | |
dc.contributor.author | Sieber, OM | |
dc.date.accessioned | 2020-12-22T02:43:29Z | |
dc.date.available | 2020-12-22T02:43:29Z | |
dc.date.issued | 2015-09-15 | |
dc.identifier | pii: bjc2015296 | |
dc.identifier.citation | Jorissen, R. N., Christie, M., Mouradov, D., Sakthianandeswaren, A., Li, S., Love, C., Xu, Z. -Z., Molloy, P. L., Jones, I. T., McLaughlin, S., Ward, R. L., Hawkins, N. J., Ruszkiewicz, A. R., Moore, J., Burgess, A. W., Busam, D., Zhao, Q., Strausberg, R. L., Lipton, L. ,... Sieber, O. M. (2015). Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer. BRITISH JOURNAL OF CANCER, 113 (6), pp.979-988. https://doi.org/10.1038/bjc.2015.296. | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | http://hdl.handle.net/11343/257698 | |
dc.description.abstract | BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. METHODS: APC prognostic value was evaluated in 746 stage I-IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to identify a gene signature that could classify APC mutation status, and classifier ability to predict prognosis was examined in an independent cohort. RESULTS: Wild-type APC microsatellite stable (APC-wt/MSS) tumours from the proximal colon showed poorer overall and recurrence-free survival (OS, RFS) than APC-mt/MSS proximal, APC-wt/MSS distal and APC-mt/MSS distal tumours (OS HR⩾1.79, P⩽0.015; RFS HR⩾1.88, P⩽0.026). APC was a stronger prognostic indicator than BRAF, KRAS, PIK3CA, TP53, CpG island methylator phenotype or chromosomal instability status (P⩽0.036). Microarray analysis similarly revealed poorer survival in MSS proximal cancers with an APC-wt-like signature (P=0.019). APC status did not affect outcomes in MSI tumours. In a validation on 206 patients with proximal colon cancer, APC-wt-like signature MSS cases showed poorer survival than APC-mt-like signature MSS or MSI cases (OS HR⩾2.50, P⩽0.010; RFS HR⩾2.14, P⩽0.025). Poor prognosis APC-wt/MSS proximal tumours exhibited features of the sessile serrated neoplasia pathway (P⩽0.016). CONCLUSIONS: APC-wt status is a marker of poor prognosis in MSS proximal colon cancer. | |
dc.language | English | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.title | Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1038/bjc.2015.296 | |
melbourne.affiliation.department | Medical Biology (W.E.H.I.) | |
melbourne.affiliation.department | Surgery (RMH) | |
melbourne.affiliation.department | Surgery (Western Health) | |
melbourne.affiliation.department | Sir Peter MacCallum Department of Oncology | |
melbourne.affiliation.department | Medicine and Radiology | |
melbourne.source.title | British Journal of Cancer | |
melbourne.source.volume | 113 | |
melbourne.source.issue | 6 | |
melbourne.source.pages | 979-988 | |
dc.rights.license | CC BY-NC-SA | |
melbourne.elementsid | 998994 | |
melbourne.contributor.author | Love, Christopher | |
melbourne.contributor.author | Mouradov, Dmitri | |
melbourne.contributor.author | McLaughlin, Stephen | |
melbourne.contributor.author | Lipton, Lara | |
melbourne.contributor.author | Gibbs, Peter | |
melbourne.contributor.author | Sieber, Oliver | |
melbourne.contributor.author | Burgess, Antony | |
melbourne.contributor.author | Desai, Jayesh | |
melbourne.contributor.author | Jorissen, Robert | |
melbourne.contributor.author | Jones, Ian | |
melbourne.contributor.author | Christie, Michael | |
melbourne.contributor.author | SAKTHIANANDESWAREN, ANURATHA | |
dc.identifier.eissn | 1532-1827 | |
melbourne.accessrights | Open Access | |