The association between cingulate cortex glutamate concentration and delay discounting is mediated by resting state functional connectivity

Download
Author
Schmaal, L; Goudriaan, AE; van der Meer, J; van den Brink, W; Veltman, DJDate
2012-09-01Source Title
Brain and BehaviorPublisher
WILEYUniversity of Melbourne Author/s
Schmaal, LianneAffiliation
Centre for Youth Mental HealthMetadata
Show full item recordDocument Type
Journal ArticleCitations
Schmaal, L., Goudriaan, A. E., van der Meer, J., van den Brink, W. & Veltman, D. J. (2012). The association between cingulate cortex glutamate concentration and delay discounting is mediated by resting state functional connectivity. BRAIN AND BEHAVIOR, 2 (5), pp.553-562. https://doi.org/10.1002/brb3.74.Access Status
Open AccessDOI
10.1002/brb3.74Abstract
Humans vary in their ability to delay gratification and impulsive decision making is a common feature in various psychiatric disorders. The level of delay discounting is a relatively stable psychological trait, and therefore neural processes implicated in delay discounting are likely to be based on the overall functional organization of the brain (under task-free conditions) in which state-dependent shifts from baseline levels occur. The current study investigated whether delay discounting can be predicted by intrinsic properties of brain functioning. Fourteen healthy male subjects performed a delay discounting task. In addition, resting state functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (¹H MRS) were used to investigate the relationship between individual differences in delay discounting and molecular and regional measures of resting state (baseline) activity of dorsal anterior cingulate cortex (dACC). Results showed that delay discounting was associated with both dACC glutamate concentrations and resting state functional connectivity of the dACC with a midbrain region including ventral tegmental area and substantia nigra. In addition, a neural pathway was established, showing that the effect of glutamate concentrations in the dACC on delay discounting is mediated by functional connectivity of the dACC with the midbrain. The current findings are important to acknowledge because spontaneous intrinsic brain processes have been proposed to be a potential promising biomarker of disease and impulsive decision making is associated with several psychiatric disorders.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References