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dc.contributor.authorCrum, WR
dc.contributor.authorDanckaers, F
dc.contributor.authorHuysmans, T
dc.contributor.authorCotel, M-C
dc.contributor.authorNatesan, S
dc.contributor.authorModo, MM
dc.contributor.authorSijbers, J
dc.contributor.authorWilliams, SCR
dc.contributor.authorKapur, S
dc.contributor.authorVernon, AC
dc.date.accessioned2020-12-22T03:13:30Z
dc.date.available2020-12-22T03:13:30Z
dc.date.issued2016-11-01
dc.identifierpii: S0033291716001768
dc.identifier.citationCrum, W. R., Danckaers, F., Huysmans, T., Cotel, M. -C., Natesan, S., Modo, M. M., Sijbers, J., Williams, S. C. R., Kapur, S. & Vernon, A. C. (2016). Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss. PSYCHOLOGICAL MEDICINE, 46 (15), pp.3081-3093. https://doi.org/10.1017/S0033291716001768.
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/11343/257806
dc.description.abstractBACKGROUND: One of the most consistently reported brain abnormalities in schizophrenia (SCZ) is decreased volume and shape deformation of the hippocampus. However, the potential contribution of chronic antipsychotic medication exposure to these phenomena remains unclear. METHOD: We examined the effect of chronic exposure (8 weeks) to clinically relevant doses of either haloperidol (HAL) or olanzapine (OLZ) on adult rat hippocampal volume and shape using ex vivo structural MRI with the brain retained inside the cranium to prevent distortions due to dissection, followed by tensor-based morphometry (TBM) and elastic surface-based shape deformation analysis. The volume of the hippocampus was also measured post-mortem from brain tissue sections in each group. RESULTS: Chronic exposure to either HAL or OLZ had no effect on the volume of the hippocampus, even at exploratory thresholds, which was confirmed post-mortem. In contrast, shape deformation analysis revealed that chronic HAL and OLZ exposure lead to both common and divergent shape deformations (q = 0.05, FDR-corrected) in the rat hippocampus. In particular, in the dorsal hippocampus, HAL exposure led to inward shape deformation, whereas OLZ exposure led to outward shape deformation. Interestingly, outward shape deformations that were common to both drugs occurred in the ventral hippocampus. These effects remained significant after controlling for hippocampal volume suggesting true shape changes. CONCLUSIONS: Chronic exposure to either HAL or OLZ leads to both common and divergent effects on rat hippocampal shape in the absence of volume change. The implications of these findings for the clinic are discussed.
dc.languageEnglish
dc.publisherCAMBRIDGE UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleChronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss
dc.typeJournal Article
dc.identifier.doi10.1017/S0033291716001768
melbourne.affiliation.departmentMedicine Dentistry & Health Sciences
melbourne.source.titlePsychological Medicine
melbourne.source.volume46
melbourne.source.issue15
melbourne.source.pages3081-3093
dc.rights.licenseCC BY
melbourne.elementsid1176093
melbourne.contributor.authorKapur, Shitij
dc.identifier.eissn1469-8978
melbourne.accessrightsOpen Access


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