University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medical Education
  • Medical Education - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Medical Education
  • Medical Education - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    White matter integrity as a predictor of response to treatment in first episode psychosis

    Thumbnail
    Download
    Published version (537.6Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    98
    87
    Author
    Marques, TR; Taylor, H; Chaddock, C; Dell'Acqua, F; Handley, R; Reinders, AATS; Mondelli, V; Bonaccorso, S; DiForti, M; Simmons, A; ...
    Date
    2014-01-01
    Source Title
    Brain: a journal of neurology
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Kapur, Shitij; Murray, Robin
    Affiliation
    Medical Education
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Marques, T. R., Taylor, H., Chaddock, C., Dell'Acqua, F., Handley, R., Reinders, A. A. T. S., Mondelli, V., Bonaccorso, S., DiForti, M., Simmons, A., David, A. S., Murray, R. M., Pariante, C. M., Kapur, S. & Dazzan, P. (2014). White matter integrity as a predictor of response to treatment in first episode psychosis. BRAIN, 137 (Pt 1), pp.172-182. https://doi.org/10.1093/brain/awt310.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257842
    DOI
    10.1093/brain/awt310
    Abstract
    The integrity of brain white matter connections is central to a patient's ability to respond to pharmacological interventions. This study tested this hypothesis using a specific measure of white matter integrity, and examining its relationship to treatment response using a prospective design in patients within their first episode of psychosis. Diffusion tensor imaging data were acquired in 63 patients with first episode psychosis and 52 healthy control subjects (baseline). Response was assessed after 12 weeks and patients were classified as responders or non-responders according to treatment outcome. At this second time-point, they also underwent a second diffusion tensor imaging scan. Tract-based spatial statistics were used to assess fractional anisotropy as a marker of white matter integrity. At baseline, non-responders showed lower fractional anisotropy than both responders and healthy control subjects (P < 0.05; family-wise error-corrected), mainly in the uncinate, cingulum and corpus callosum, whereas responders were indistinguishable from healthy control subjects. After 12 weeks, there was an increase in fractional anisotropy in both responders and non-responders, positively correlated with antipsychotic exposure. This represents one of the largest, controlled investigations of white matter integrity and response to antipsychotic treatment early in psychosis. These data, together with earlier findings on cortical grey matter, suggest that grey and white matter integrity at the start of treatment is an important moderator of response to antipsychotics. These findings can inform patient stratification to anticipate care needs, and raise the possibility that antipsychotics may restore white matter integrity as part of the therapeutic response.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Medical Education - Research Publications [497]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors