Show simple item record

dc.contributor.authorVongsuvanh, R
dc.contributor.authorvan der Poorten, D
dc.contributor.authorIseli, T
dc.contributor.authorStrasser, SI
dc.contributor.authorMcCaughan, GW
dc.contributor.authorGeorge, J
dc.date.accessioned2020-12-22T03:26:09Z
dc.date.available2020-12-22T03:26:09Z
dc.date.issued2016-05-24
dc.identifierpii: PONE-D-16-09115
dc.identifier.citationVongsuvanh, R., van der Poorten, D., Iseli, T., Strasser, S. I., McCaughan, G. W. & George, J. (2016). Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma. PLOS ONE, 11 (5), https://doi.org/10.1371/journal.pone.0155800.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/257852
dc.description.abstractUNLABELLED: Robust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with chronic liver disease (CLD) and 86 healthy controls (HC). Based on the performance of each biomarker, we assessed a separate longitudinal cohort of 28 HCC patients, at and before cancer diagnosis. Serum levels of MDK and OPN were higher in HCC patients compared to cirrhosis, CLD and HC groups. DKK1 was not different between cases and controls. More than half of HCC patients had normal AFP. In this AFP-negative HCC cohort, 59.18% (n = 29/49) had elevated MDK, applying the optimal cut-off of 0.44 ng/ml. Using AFP ≥ 20 IU/ml or MDK ≥ 0.44 ng/ml, a significantly greater number (76.7%; n = 66/86) of HCC cases were detected. The area under the receiver operating curve for MDK was superior to AFP and OPN in NASH-HCC diagnosis. In the longitudinal cohort, MDK was elevated in 15/28 (54%) of HCC patients at diagnosis, of whom 67% had elevated MDK 6 months prior. CONCLUSION: AFP and MDK have a complementary role in HCC detection. MDK increases the diagnostic yield in AFP-negative HCC and has greater diagnostic performance than AFP, OPN and DKK-1 in the diagnosis of NASH-HCC. Additionally, MDK has a promising role in the pre-clinical diagnosis of HCC.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.titleMidkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0155800
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue5
dc.rights.licenseCC BY
melbourne.elementsid1177655
melbourne.contributor.authorIseli, Tristan
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record