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    The role of MDM2 and MDM4 in breast cancer development and prevention

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    Author
    Haupt, S; Vijayakumaran, R; Miranda, PJ; Burgess, A; Lim, E; Haupt, Y
    Date
    2017-02-01
    Source Title
    Journal of Molecular Cell Biology
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Haupt, Ygal; Haupt, Susan; Vijayakumaran, Reshma; Alphonse Miranda, Panimaya Jeffreena Miranda
    Affiliation
    Sir Peter MacCallum Department of Oncology
    Clinical Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Haupt, S., Vijayakumaran, R., Miranda, P. J., Burgess, A., Lim, E. & Haupt, Y. (2017). The role of MDM2 and MDM4 in breast cancer development and prevention. JOURNAL OF MOLECULAR CELL BIOLOGY, 9 (1), pp.53-61. https://doi.org/10.1093/jmcb/mjx007.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257869
    DOI
    10.1093/jmcb/mjx007
    NHMRC Grant code
    NHMRC/1123057
    NHMRC/1063389
    Abstract
    The major cause of death from breast cancer is not the primary tumour, but relapsing, drug-resistant, metastatic disease. Identifying factors that contribute to aggressive cancer offers important leads for therapy. Inherent defence against carcinogens depends on the individual molecular make-up of each person. Important molecular determinants of these responses are under the control of the mouse double minute (MDM) family: comprised of the proteins MDM2 and MDM4. In normal, healthy adult cells, the MDM family functions to critically regulate measured, cellular responses to stress and subsequent recovery. Proper function of the MDM family is vital for normal breast development, but also for preserving genomic fidelity. The MDM family members are best characterized for their negative regulation of the major tumour suppressor p53 to modulate stress responses. Their impact on other cellular regulators is emerging. Inappropriately elevated protein levels of the MDM family are highly associated with an increased risk of cancer incidence. Exploration of the MDM family members as cancer therapeutic targets is relevant for designing tailored anti-cancer treatments, but successful approaches must strategically consider the impact on both the target cancer and adjacent healthy cells and tissues. This review focuses on recent findings pertaining to the role of the MDM family in normal and malignant breast cells.

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