GENOMIC ORGANIZATION OF THE MOUSE PORE-FORMING PROTEIN (PERFORIN) GENE AND LOCALIZATION TO CHROMOSOME-10 - SIMILARITIES TO AND DIFFERENCES FROM C9
AuthorTRAPANI, JA; KWON, BS; KOZAK, CA; CHINTAMANENI, C; YOUNG, JDE; DUPONT, B
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sTrapani, Joseph
AffiliationSir Peter MacCallum Department of Oncology
Document TypeJournal Article
CitationsTRAPANI, J. A., KWON, B. S., KOZAK, C. A., CHINTAMANENI, C., YOUNG, J. D. E. & DUPONT, B. (1990). GENOMIC ORGANIZATION OF THE MOUSE PORE-FORMING PROTEIN (PERFORIN) GENE AND LOCALIZATION TO CHROMOSOME-10 - SIMILARITIES TO AND DIFFERENCES FROM C9. JOURNAL OF EXPERIMENTAL MEDICINE, 171 (2), pp.545-557. https://doi.org/10.1084/jem.171.2.545.
Access StatusOpen Access
Genomic clones encompassing the entire coding region of the mouse lymphocyte pore-forming protein gene (Pfp) have been isolated and used to determine its intron-exon organization. In contrast to C9, Pfp has a simple structure, consisting of only three exons (two of which encode polypeptide), a large 5' intron, and a single, smaller intron that is situated approximately one-third of the way through the protein-coding portions of the gene. The regions encoding the homologous domains of PFP and C9 are encoded on exons 7, 8, 9, and 10 of C9, but form only approximately half of the open reading frame of exon III in Pfp. Although encoding polypeptides with related functions, the two genes possess such sharply contrasting structures as to suggest that their analogous regions may have risen independently, by a process of convergent evolution. Using a panel of somatic cell hybrid cell lines, Pfp has been mapped to chromosome 10.
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