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dc.contributor.authorTRAPANI, JA
dc.contributor.authorKWON, BS
dc.contributor.authorKOZAK, CA
dc.contributor.authorCHINTAMANENI, C
dc.contributor.authorYOUNG, JDE
dc.contributor.authorDUPONT, B
dc.date.accessioned2020-12-22T03:32:28Z
dc.date.available2020-12-22T03:32:28Z
dc.date.issued1990-02-01
dc.identifier.citationTRAPANI, J. A., KWON, B. S., KOZAK, C. A., CHINTAMANENI, C., YOUNG, J. D. E. & DUPONT, B. (1990). GENOMIC ORGANIZATION OF THE MOUSE PORE-FORMING PROTEIN (PERFORIN) GENE AND LOCALIZATION TO CHROMOSOME-10 - SIMILARITIES TO AND DIFFERENCES FROM C9. JOURNAL OF EXPERIMENTAL MEDICINE, 171 (2), pp.545-557. https://doi.org/10.1084/jem.171.2.545.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257875
dc.description.abstractGenomic clones encompassing the entire coding region of the mouse lymphocyte pore-forming protein gene (Pfp) have been isolated and used to determine its intron-exon organization. In contrast to C9, Pfp has a simple structure, consisting of only three exons (two of which encode polypeptide), a large 5' intron, and a single, smaller intron that is situated approximately one-third of the way through the protein-coding portions of the gene. The regions encoding the homologous domains of PFP and C9 are encoded on exons 7, 8, 9, and 10 of C9, but form only approximately half of the open reading frame of exon III in Pfp. Although encoding polypeptides with related functions, the two genes possess such sharply contrasting structures as to suggest that their analogous regions may have risen independently, by a process of convergent evolution. Using a panel of somatic cell hybrid cell lines, Pfp has been mapped to chromosome 10.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.titleGENOMIC ORGANIZATION OF THE MOUSE PORE-FORMING PROTEIN (PERFORIN) GENE AND LOCALIZATION TO CHROMOSOME-10 - SIMILARITIES TO AND DIFFERENCES FROM C9
dc.typeJournal Article
dc.identifier.doi10.1084/jem.171.2.545
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume171
melbourne.source.issue2
melbourne.source.pages545-557
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1179884
melbourne.contributor.authorTrapani, Joseph
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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