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    Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trondelag health study (HUNT)

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    Author
    Pahau, H; Brown, MA; Paul, S; Thomas, R; Videm, V
    Date
    2014-01-01
    Source Title
    Arthritis Research and Therapy
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Paul, Sanjoy
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Pahau, H., Brown, M. A., Paul, S., Thomas, R. & Videm, V. (2014). Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trondelag health study (HUNT). ARTHRITIS RESEARCH & THERAPY, 16 (2), https://doi.org/10.1186/ar4527.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257902
    DOI
    10.1186/ar4527
    Abstract
    INTRODUCTION: Patients with rheumatoid arthritis (RA) have increased risk of cardiovascular (CV) events. We sought to test the hypothesis that due to increased inflammation, CV disease and risk factors are associated with increased risk of future RA development. METHODS: The population-based Nord-Trøndelag health surveys (HUNT) were conducted among the entire adult population of Nord-Trøndelag, Norway. All inhabitants 20 years or older were invited, and information was collected through comprehensive questionnaires, a clinical examination, and blood samples. In a cohort design, data from HUNT2 (1995-1997, baseline) and HUNT3 (2006-2008, follow-up) were obtained to study participants with RA (n = 786) or osteoarthritis (n = 3,586) at HUNT3 alone, in comparison with individuals without RA or osteoarthritis at both times (n = 33,567). RESULTS: Female gender, age, smoking, body mass index, and history of previous CV disease were associated with self-reported incident RA (previous CV disease: odds ratio 1.52 (95% confidence interval 1.11-2.07). The findings regarding previous CV disease were confirmed in sensitivity analyses excluding participants with psoriasis (odds ratio (OR) 1.70 (1.23-2.36)) or restricting the analysis to cases with a hospital diagnosis of RA (OR 1.90 (1.10-3.27)) or carriers of the shared epitope (OR 1.76 (1.13-2.74)). History of previous CV disease was not associated with increased risk of osteoarthritis (OR 1.04 (0.86-1.27)). CONCLUSION: A history of previous CV disease was associated with increased risk of incident RA but not osteoarthritis.

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