Influenza C infections in Western Australia and Victoria from 2008 to 2014
AuthorJelley, L; Levy, A; Deng, Y-M; Spirason, N; Lang, J; Buettner, I; Druce, J; Blyth, C; Effler, P; Smith, D; ...
Source TitleInfluenza and Other Respiratory Viruses
University of Melbourne Author/sBarr, Ian
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsJelley, L., Levy, A., Deng, Y. -M., Spirason, N., Lang, J., Buettner, I., Druce, J., Blyth, C., Effler, P., Smith, D. & Barr, I. G. (2016). Influenza C infections in Western Australia and Victoria from 2008 to 2014. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 10 (6), pp.455-461. https://doi.org/10.1111/irv.12402.
Access StatusOpen Access
BACKGROUND: Influenza C is usually considered a minor cause of respiratory illness in humans with many infections being asymptomatic or clinically mild. Large outbreaks can occur periodically resulting in significant morbidity. OBJECTIVES: This study aimed at analyzing the available influenza C clinical samples from two widely separated states of Australia, collected over a 7-year period and to compare them with influenza C viruses detected in other parts of the world in recent years. PATIENTS/METHODS: Between 2008 and 2014, 86 respiratory samples that were influenza C positive were collected from subjects with influenza-like illness living in the states of Victoria and Western Australia. A battery of other respiratory viruses were also tested for in these influenza C-positive samples. Virus isolation was attempted on all of these clinical samples, and gene sequencing was performed on all influenza C-positive cultures. RESULTS AND CONCLUSIONS: Detections of influenza C in respiratory samples were sporadic in most years studied, but higher rates of infection occurred in 2012 and 2014. Many of the patients with influenza C had coinfections with other respiratory pathogens. Phylogenetic analysis of the full-length hemagglutinin-esterase-fusion (HE) gene found that most of the viruses grouped in the C/Sao Paulo/378/82 clade with the remainder grouping in the C/Kanagawa/1/76 clade.
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