Show simple item record

dc.contributor.authorMaksimovic, J
dc.contributor.authorGagnon-Bartsch, JA
dc.contributor.authorSpeed, TP
dc.contributor.authorOshlack, A
dc.date.accessioned2020-12-22T03:43:30Z
dc.date.available2020-12-22T03:43:30Z
dc.date.issued2015-09-18
dc.identifierpii: gkv526
dc.identifier.citationMaksimovic, J., Gagnon-Bartsch, J. A., Speed, T. P. & Oshlack, A. (2015). Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data. NUCLEIC ACIDS RESEARCH, 43 (16), https://doi.org/10.1093/nar/gkv526.
dc.identifier.issn0305-1048
dc.identifier.urihttp://hdl.handle.net/11343/257913
dc.description.abstractDue to their relatively low-cost per sample and broad, gene-centric coverage of CpGs across the human genome, Illumina's 450k arrays are widely used in large scale differential methylation studies. However, by their very nature, large studies are particularly susceptible to the effects of unwanted variation. The effects of unwanted variation have been extensively documented in gene expression array studies and numerous methods have been developed to mitigate these effects. However, there has been much less research focused on the appropriate methodology to use for accounting for unwanted variation in methylation array studies. Here we present a novel 2-stage approach using RUV-inverse in a differential methylation analysis of 450k data and show that it outperforms existing methods.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRemoving unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data
dc.typeJournal Article
dc.identifier.doi10.1093/nar/gkv526
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.affiliation.departmentSchool of Physics
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleNucleic Acids Research
melbourne.source.volume43
melbourne.source.issue16
dc.rights.licenseCC BY
melbourne.elementsid1179844
melbourne.contributor.authorMaksimovic, Jovana
melbourne.contributor.authorSpeed, Terence
melbourne.contributor.authorOshlack, Alicia
dc.identifier.eissn1362-4962
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record