Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif

Download
Author
Luczo, JM; Stambas, J; Durr, PA; Michalski, WP; Bingham, JDate
2015-11-01Source Title
Reviews in Medical VirologyPublisher
WILEYUniversity of Melbourne Author/s
Stambas, JohnAffiliation
Microbiology and ImmunologyMetadata
Show full item recordDocument Type
Journal ArticleCitations
Luczo, J. M., Stambas, J., Durr, P. A., Michalski, W. P. & Bingham, J. (2015). Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif. REVIEWS IN MEDICAL VIROLOGY, 25 (6), pp.406-430. https://doi.org/10.1002/rmv.1846.Access Status
Open AccessDOI
10.1002/rmv.1846Abstract
The emergence of H5N1 highly pathogenic avian influenza has caused a heavy socio-economic burden through culling of poultry to minimise human and livestock infection. Although human infections with H5N1 have to date been limited, concerns for the pandemic potential of this zoonotic virus have been greatly intensified following experimental evidence of aerosol transmission of H5N1 viruses in a mammalian infection model. In this review, we discuss the dominance of the haemagglutinin cleavage site motif as a pathogenicity determinant, the host-pathogen molecular interactions driving cleavage activation, reverse genetics manipulations and identification of residues key to haemagglutinin cleavage site functionality and the mechanisms of cell and tissue damage during H5N1 infection. We specifically focus on the disease in chickens, as it is in this species that high pathogenicity frequently evolves and from which transmission to the human population occurs. With >75% of emerging infectious diseases being of zoonotic origin, it is necessary to understand pathogenesis in the primary host to explain spillover events into the human population.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References