Skeletal intramyocellular lipid metabolism and insulin resistance.
AuthorLi, Y; Xu, S; Zhang, X; Yi, Z; Cichello, S
Source TitleBiophysics Reports
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sCichello, Simon
AffiliationAgriculture and Food Systems
Document TypeJournal Article
CitationsLi, Y., Xu, S., Zhang, X., Yi, Z. & Cichello, S. (2015). Skeletal intramyocellular lipid metabolism and insulin resistance.. Biophys Rep, 1 (2), pp.90-98. https://doi.org/10.1007/s41048-015-0013-0.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762133
Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References