Skeletal intramyocellular lipid metabolism and insulin resistance.

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    Author
    Li, Y; Xu, S; Zhang, X; Yi, Z; Cichello, S
    Date
    2015
    Source Title
    Biophysics Reports
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Cichello, Simon
    Affiliation
    Agriculture and Food Systems
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Li, Y., Xu, S., Zhang, X., Yi, Z. & Cichello, S. (2015). Skeletal intramyocellular lipid metabolism and insulin resistance.. Biophys Rep, 1 (2), pp.90-98. https://doi.org/10.1007/s41048-015-0013-0.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257948
    DOI
    10.1007/s41048-015-0013-0
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762133
    Abstract
    Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.

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