Skeletal intramyocellular lipid metabolism and insulin resistance.

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Li, Y; Xu, S; Zhang, X; Yi, Z; Cichello, SDate
2015Source Title
Biophysics ReportsPublisher
Springer Science and Business Media LLCUniversity of Melbourne Author/s
Cichello, SimonAffiliation
Agriculture and Food SystemsMetadata
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Journal ArticleCitations
Li, Y., Xu, S., Zhang, X., Yi, Z. & Cichello, S. (2015). Skeletal intramyocellular lipid metabolism and insulin resistance.. Biophys Rep, 1 (2), pp.90-98. https://doi.org/10.1007/s41048-015-0013-0.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762133Abstract
Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.
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